The immunoglobulin receptor of B-cell lymphomas constitutes a specific tumor antigen (idiotype) and a target for active immunotherapy. Encouraging results have been reported in phase II trials after s.c. vaccination of follicular lymphoma patients during clinical remission with idiotype produced from eukaryotic cell lines and coupled to an immunogenic carrier macromolecule. We have developed a ...

with the plasmid dna from a clinical isolate of enterotoxigenic escherichia coli (etec) h 10407 as template, pcr-mediated cloning of the sequence encoding the heat-labile toxin b subunit (l t -b) has been carried out. then this sequence was recloned into the ptrc 99a and pet23a expression vectors to give the pjasmids ptrcltb and petltb, respectively. after induction, the former plasmid provides...

background: hepatitis b infection is a major public health problem worldwide. dental students who are frequently in contact with body fluids like blood and saliva are still at high risk for hbv exposure. the aim of this study was to evaluate the effectiveness of hbv vaccine and personal factors associated with serologic evidence of the immune response. methods: a descriptive-cross sectional stu...

Background: Hepatitis B virus potentially accelerates graft rejection and mortality in renal transplantation population. Vaccination of graft candidates without prior immunization against HBV seems essential before transplantation but some candidates of transplantation have not received HBV vaccine at the time of receiving graft. We aimed to evaluate immunogenicity of ...

background: due to their similar routes of transmission, human immunodeficiency virus (hiv) and hepatitis b virus (hbv) co-infection occurs considerably. hbv infection progresses more rapidly in hiv-infected patients. therefore, hbv vaccination of all non-immune hiv infected patients is recommended. on the other hand, hiv-infected subjects have suboptimal responses to hbv vaccine. in this study...

background: available drugs are not able to eradicate intracellular viral dna in patients with hepatitis b virus (hbv) infections. hbsag vaccine could induce immunity and subsequently eradicate hepatitis b virus in proportions of these patients. our aim was to evaluate the efficacy of hbsag as a mode of therapy in inactive carriers. materials and methods: forty two consecutive patients of inact...

introduction: vaccination with the major surface antigen of hepatitis b virus (hbsag) induces anti-hbs antibody production and level of 10 iu/l is considered protective. it has been shown that the level of anti-hbs antibody does wane after vaccination. the aim of this study was to evaluate the persistence of anti-hbs antibodies in healthy iranian children 10 years after primary vaccination. met...

conclusions these findings of the present study indicate that the recombinant coree1e2 glycoprotein is effective in inducing neutralizing antibodies, and is an influential hcv vaccine candidate. results in our study, the virus-like particle of rcoree1e2 with 70 nm size, was shown by electron microscopy and proved the self-assembly in vitro in a yeast expression system. materials and methods by ...

BACKGROUND Patients with chronic renal disease should be vaccinated as soon as dialysis is forestalled, and this could improve the seroconversion of hepatitis B vaccination. OBJECTIVES In this study, we aimed to compare seroconversion and immune response rates using 4 doses of 40 μg and 3 doses of 20 μg Euvax B recombinant Hepatitis B surface Antigen (HBs Ag) vaccine administered to predialys...

conclusions dental academics were unsure about the means of infection and prevention against hbv. many of them had not completed the immunization scheme and did not have the test of seroconversion. the serological analysis revealed unprotection, even after students completed the vaccination schedule. results of the 179 students surveyed, 58.1% knew about the degree of virulence of the hepatitis...