OBJECTIVES Invasive infections caused by KPC-producing Klebsiella pneumoniae (KPCKP) are associated with very high mortality. Because infection is usually preceded by rectal colonization, we investigated if decolonization therapy (DT) with aminoglycosides had a protective effect in selected patients. METHODS Patients with rectal colonization by colistin-resistant KPCKP who were at high risk o...

AIMS The contribution of dogs and cats as reservoirs of antimicrobial resistant enterococci remains largely undefined. This is increasingly important considering the possibility of transfer of bacteria from companion animals to the human host. In this study, dogs and cats from veterinary clinics were screened for the presence of enterococci. METHODS AND RESULTS A total of 420 enterococci were...

Background: In order to improve the evaluation of possible rectal toxicity based on the rectal normal tissue complication probability (NTCP), we consider the fractional dependence of the NTCP on the wall thickness (tW) and rectal displacement (RM). Materials and Methods: The two-dimensional NTCP model (NTCP2D) was developed using radiotherapy plans of ten randomly selected patients with prostat...

conclusions evaluation of iranian traditional dosage forms like vaginal and rectal types could be an attractive topic of research and the current study can briefly represent the iranian traditional pharmaceutical knowledge on vaginal and rectal drug delivery. objectives the aim of this study is the investigation about iranian traditional pharmaceutical dosage forms of vaginal and rectal medicat...

in recent years, tuberculosis has had a significant rise, caused mainly by the epidemic of acquired immunodeficiency syndrome. the anorectal tuberculosis is a very rare presentation. herein, we presented a 67-year-old man who has had renal transplantation and presented with hematochezia and painful defecation since 6 months before. biopsy was taken from the lower rectal ulcerated lesion. histop...

BACKGROUND Prior studies have shown an increase in multidrug-resistant (MDR) E. coli colonization from two percent in U.S.-based to 11 % in deployed, healthy military personnel. It is unclear if colonization with MDR organisms occurs through deployment exposures or risks related to routine overseas travel. This study prospectively evaluates rates and risk factors associated with MDR gram-negati...

To the Editor—Multidrug-resistant organisms (MDROs) have recently caused infection outbreaks with increased morbidity and mortality. Colonization of the inanimate hospital environment and intestines may contribute to the increased prevalence of MDROs. To prevent the spread of MDROs in the intensive care unit (ICU), the correlation between colonization of MDROs and the length of patient hospital...

To determine the epidemiology and risk factors for carbapenem-resistant Pseudomonas aeruginosa (CR-PA) digestive tract colonization, weekly rectal and pharyngeal swabs were obtained in two serial incidence surveys (266 patients). Forty-two (16%) patients were CR-PA colonized (12 [29%] on admission and 30 [71%] in intensive care units). Pulsed-field gel electrophoresis showed extensive clonal di...

OBJECTIVE To evaluate the efficacy of a standardized regimen for decolonization of methicillin-resistant Staphylococcus aureus (MRSA) carriers and to identify factors influencing decolonization treatment failure. DESIGN Prospective cohort study from January 2002 to April 2007, with a mean follow-up period of 36 months. SETTING University hospital with 750 beds and 27,000 admissions/year. ...