Patients with selective immune defects have provided vivid evidence of the specific host factors that mediate defense against the pneumococcus. Rates of invasive pneumococcal infections may be increased among patients with deficiencies of complement components (involving either the classical or alternative pathway) [1–3], decreased phagocyte number and function (including neutropenia, asplenia,...

Urinary tract infections (UTIs), mostly caused by uropathogenic E. coli (UPEC), are important human infections. Understanding UTI pathogenesis is for combating the rise in treatment failure and recurrent

Humoral immune deficiencies have been associated with noninfectious disease complications including autoimmune cytopenias and pulmonary disease. Herein we present a patient who underwent splenectomy for autoimmune cytopenias and subsequently was diagnosed with humoral immune deficiency in the context of recurrent infections. Immunoglobulin analysis prior to initiation of intravenous immunoglobu...

To determine whether genetic factors influence the human antibody response to polysaccharides, we correlated Ig allotypes with the concentrations of antibody to 14 bacterial capsular antigens in 130 actively immunized Caucasian adults. The 88 individuals possessing G2m(n), an allotype antigen of IgG2 subclass heavy chains, had significantly higher postimmunization antibody levels to Haemophilus...

OBJECTIVE Language is almost always affected in fragile X syndrome (FXS), and a delay in language acquisition is one of the first characteristics. The aim of this work was to study the effect of recurrent middle ear infections on the language profile in boys with FXS. STUDY DESIGN Prospective case series. SETTING Academic Medical Center. SUBJECTS AND METHODS The present study was conducte...