BACKGROUND Determination of fetal aneuploidy is central to evaluation of recurrent pregnancy loss (RPL). However, obtaining this information at the time of a miscarriage is not always possible or may not have been ordered. Here we report on "rescue karyotyping", wherein DNA extracted from archived paraffin-embedded pregnancy loss tissue from a prior dilation and curettage (D&C) is evaluated by ...

Demographics The true prevalence of vaginal and uterine duplications is unknown because the anomaly may not manifest until the reproductive years of the individual.2 Although a prevalence of 3.2% in the healthy fertile population has been quoted in one study, another study quoted an incidence of 0.1–0.5%.3, 4 Rackow and associates reported an incidence of 3–4% in fertile and infertile women, 5–...

We have previously shown an extensive load of somatic copy number variations (CNVs) in the human placental genome with the highest fraction detected in normal term pregnancies. Hereby, we hypothesized that insufficient promotion of CNVs may impair placental development and lead to recurrent pregnancy loss (RPL). RPL affects ~3% of couples aiming at childbirth and idiopathic RPL represents ~50% ...

Background: Recurrent early pregnancy loss is a common but frequently unexplained obstetric problem. As it happens in weeks of pregnancy, abnormal vasculogenesis and disordered cell multiplication are possible causes. Hyperhomocysteinemia associated with both these pathological processes. Objective: To assess the association between hyperhomocysteinemia recurrent loss. Materials Methods: This c...

Recent evidences associate thrombophilia with adverse pregnancy outcome. Numerous studies confirm Factor V Leiden (FVL) and Prothrombin G20210A (PT G20210A) mutations as important thrombophilia risk factors in Caucasians. However, these mutations are rare in Asians and thrombophilia investigations are therefore considered irrelevant in these patients. Hence, the status of thrombophilia-induced ...

The role of apolipoprotein E (Apo E) gene polymorphisms in the etiology of recurrent pregnancy loss (RPL) is not clearly understood. We evaluated this polymorphism in unexplained pregnancy losses in a group of Turkish women. In our prospective case-control study, 45 well-characterized RPL cases were examined for their Apo E genotypes, based on restriction fragment length polymorphism analysis o...

Introduction The mechanisms underlying the pathogenesis of recurrent pregnancy loss (RPL) and effective approaches to treat this disease still remain vague absent. Proteinases ADAMTS family play important roles in embryonic growth development. Our previous study suggest a role ADAMTS13 during pregnancy. Current Study was determine expression human endometrium its association with RPL. Material ...

Recurrent pregnancy loss (RPL) is defined as three or more sequential abortions before the 20th week of gestation. There is increasing evidence to support an immunological mechanism for the occurrence of RPL. Defective production of T helper type 2 (Th2) and/or higher production of T helper type 1 (Th1) cytokines have been reported in RPL. As cytokine gene polymorphisms may be associated with d...

INTRODUCTION Recurrent pregnancy loss (RPL) is a critical medical problem in about 0.5-2% of women. The molecular genetic background for spontaneous abortion is being increasingly understood, and some polymorphisms associated with it have been reported. This study investigates alterations of the Bax gene as a pro-apoptotic gene in women with idiopathic RPL. MATERIAL AND METHODS The frequency ...