Alarcon et al. (1) recently demonstrated that b-cell insulin secretory dysfunction is rapidly restored by exposure of islets to low-normal glucose ex vivo in db/db mice. The authors allude to the potential clinical relevance for “transient b-cell rest” in type 2 diabetes (T2D). Could transient b-cell rest be accomplished by manipulating diet? Lim et al. (2) have shown that a very low-calorie di...

background: finding new tolerable methods in weight loss has largely been an issue of interest for specialists. present study compared a novel method of calorie shifting diet (csd) with classic calorie restriction (cr) on weight loss in overweight and obese subjects. methods: seventy‑four subjects (body mass index ≥25; 37) were randomized to 4 weeks control diet, 6 weeks csd or cr diets, and 4 ...

The 2013 American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society (1) reviewed the available evidence-based literature with regard to the macronutrient content of diets and their health benefits and concluded that weight loss was similar with all types of diets as long as the diets achieved similar calorie restriction. There was moderat...

Background Dislipidaemia and increased levels of apolipoprotein B (apoB) in individuals with obesity are risk factors for development of cardiovascular disease (CVD). The aim of this study was to investigate the effect of weight loss and weight maintenance with and without liraglutide treatment on plasma lipid profiles and apoB. Methods Fifty-eight individuals with obesity (body mass index 34...

Long-term studies have found that low-carbohydrate diets are more effective for weight loss than calorie-restricted diets in the short term but equally or only marginally more effective in the long term. Low-carbohydrate diets have been linked to reduced glycogen stores and increased feelings of fatigue. We propose that reduced physical activity in response to lowered glycogen explains the dimi...

PURPOSE Estrogens and androgens are elevated in obesity and associated with increased postmenopausal breast cancer risk, but the effect of weight loss on these biomarkers is unknown. We evaluated the individual and combined effects of a reduced-calorie weight loss diet and exercise on serum sex hormones in overweight and obese postmenopausal women. PATIENTS AND METHODS We conducted a single-b...

Obesity results from an imbalance between calorie intake and calorie output. Although an excessive calorie intake is the most obvious and usual explanation for the development of obesity, a variety of factors influencing calorie expenditure may also be involved. Some of these factors may even be inborn. Recent work on controls of energy utilization, and on the relation between obesity and chang...

Abstract The present study was designed to investigate the effects of Gundelia tournefortii L. plant extract on different tissues in terms DNA damage, biochemical and antioxidant parameter values rats with high-calorie diets. With this aim, Wistar albino male were divided into 4 groups containing 6 each completed over 12 weeks duration. At end implementation process weeks, sacrificed blood tiss...

Abstract This study traces the causal effects of extreme weather events on nutritional and health outcomes among rural children in Uganda using four waves individual child survey data (2009–2014). A simultaneous regression model was applied for inference while also accounting households’ adaptive responses. The finds evidence a significant negative relationship between availability calories nut...

BACKGROUND Current guidelines for nutritional rehabilitation in hospitalized restrictive eating disorder patients recommend a cautious approach to refeeding. Several studies suggest that higher calorie diets may be safe and effective, but have traditionally excluded severely malnourished patients. The goal of this study was to evaluate the safety of a higher calorie nutritional rehabilitation p...