The redox active proteins contain redox centers. These can be organic or metal compounds and complexes, which are important for their function. The redox potentials of the cofactors represent key parameters of these proteins. In chapter 3, I described the way how we generated the structure of the artificial Cb from scratch. Then, we used that structure to evaluate the redox potentials of its tw...

The article shows didactic experiments related to chemical properties which could be easily adapted to any educational level, from primary to high school. Moreover, through of these experiments, teachers could introduce diverse relevant concepts which are normally included in the curriculum of chemistry subject depend on the educational level. Furthermore, each of these didactic experiments is ...

A hemicryptophane ligand soluble in water at neutral pH was obtained thanks to the derivatization of the cyclotribenzylene unit with three carboxylate groups. The corresponding Cu(ii) complex was then synthesized and its spectroscopic and electrochemical properties in water were investigated, showing that water solubilisation retains the geometry of the complex around the metal center but stron...

This review summarizes the history and most recent advances in aptamers and ribozymes that bind and use redox(reduction–oxidation) cofactors. Redox reactions, catalyzed by protein enzymes in an extant world, play a central role in the metabolism of numerous biological molecules in the living organisms. The burden of catalyzing these reactions in a preprotein-based world (i.e., the hypothesized ...

Complex I (NADH:ubiquinone oxidoreductase) is a membrane-bound, multisubunit enzyme. At present, there is no high-resolution structural model available for complex I and its mechanism of energy transduction is unknown. However, the subunit compositions of complex I from both eukaryotic and prokaryotic organisms have been determined, the sequences of their subunits are known and a coherent pictu...

The molecular similarity of multidrug resistance (MDR) inhibitors was evaluated using the point centred atom charge approach in an attempt to find some common features of structurally unrelated inhibitors. A series of inhibitors of bacterial MDR were studied and there is a high similarity between these in terms of their shape, presence and orientation of aromatic ring moieties. A comparison of ...