Investigating the role and interplay between individual proteins in biological processes is often performed by assessing the functional consequences of gene inactivation or removal. Depending on the sensitivity of the assay used for determining phenotype, between 66% (growth) and 53% (gene expression) of Saccharomyces cerevisiae gene deletion strains show no defect when analyzed under a single ...

this paper addresses the mixed integer reliability redundancy allocation problems to determine simultaneous allocation of optimal reliability and redundancy level of components based on three objective goals. system engineering principles suggest that the best design is the design that maximizes the system operational effectiveness and at the same time minimizes the total cost of ownership (tco...