Patterns of similarity between genomes of related species reflect the distribution of selective constraint within DNA. We analyzed alignments of 142 orthologous intergenic regions of Caenorhabditis elegans and Caenorhabditis briggsae and found a mosaic pattern with regions of high similarity (phylogenetic footprints) interspersed with non-alignable sequences. Footprints cover approximately 20% ...

Post-transcriptional upregulation is an effective way to increase the expression of transgenes and thus maximize the yields of target chemicals from metabolically engineered organisms. Refractory elements in the 3' untranslated region (UTR) that increase mRNA half-life might be available. In Saccharomyces cerevisiae, several terminator regions have shown activity in increasing the production of...

We present a compilation of over 1700 focal mechanisms for nearly 1300 earthquakes in metropolitan France and bordering regions Western Europe. It is based on both published unpublished sources (articles, reports, observatory websites) which the mechanism solutions have been verified internal consistency, corrected cases minor errors rejected major inconsistencies between parameters. The databa...

New national and international economic and social forces have reshaped national geographies in general and the characteristics of cities in particular, resulting in a range of diverse social and spatial outcomes. These outcomes, which include greater differentiation across, within and between metropolitan regions and cities, have become a feature of the economic and social forces associated wi...

Toxoplasmosis is a worldwide zoonotic disease but information regarding domestic animals in Central America is scarce and fragmented. The aim of this study was to determine the seroprevalence of Toxoplasma gondii in domestic cats and dogs in different metropolitan regions of Panama. A total of 576 samples were collected; sera from 120 cats and 456 dogs were tested using a commercial indirect en...