Least squares regression of y on x assumes that the x variate is measured without error, and minimizes the sum of squared vertical distance between the data points y and the fitted regression line. Regression of x on y minimizes the horizontal distances. Adcock [1] in 1878 suggested minimizing the sum of squared horizontal + vertical distances to the predicted values. However the idea of Adcock...

The apoptosis-inducing activity data of a series of 4-aryl-4H-chromenes based on three cell lines (human breast cancer cell line T47D, human non-smal cell lung cancer cell line H1299, and human colorectal cancer cell line DLD-1) have been subjected to quantitative structure-activity relationship (QSAR) analysis. A collection of chemometrics methods including multiple linear regression (MLR), fa...

BACKGROUND Busulfan (Bu) requires therapeutic drug monitoring (TDM) in subjects undergoing a conditioning regimen for hematopoietic stem cell transplantation (HSCT). To speed up the procedure and increase reproducibility, we improved our routine LC-MS/MS assay using the on-line solid-phase extraction (SPE) of samples. METHODS A protein precipitation (PP) step was performed before the on-line ...