In vitro studies reveal that nuclear receptor coactivators enhance the transcriptional activity of steroid receptors, including estrogen (ER) and progestin receptors (PR), through ligand-dependent interactions. Whereas work from our laboratory and others shows that steroid receptor coactivator-1 (SRC-1) is essential for efficient ER and PR action in brain, very little is known about receptor-co...

Monoclonal antibodies (MAhs). recently produced against human progesterone receptors (PR), were used for immunocytochemical local ization of PR. The specificity of the immunocytochemical assay for PR was demonstrated by incubation with control M Mis. preabsorption of M Alis with highly purified human PR, and by the cell and tissue distribution of the immunostaining reaction. With human breast c...

the aim of this study was to investigate the effect of three types of resistance training program on girls' physical fitness. 30 girls were divided into 3 groups: plyometric training with vascular occlusion (plo), plyometric training without vascular occlusion (pl) and power-resistance training (pr). training programs were conducted for six weeks. physical fitness tests were conducted befo...

The human immunodeficiency virus type 1 (HIV-1) Tat protein enhances reverse transcription, but it is not known whether Tat acts directly on the reverse transcription complex or through indirect mechanisms. Since processing of Tat by HIV protease (PR) might mask its presence and, at least in part, explain this lack of data, we asked whether Tat can be cleaved by PR. We used a rabbit reticulocyt...

The progesterone receptor (PR), a ligand-activated transcription factor, recruits the primary coactivator steroid receptor coactivator-1 (SRC-1) gene promoters. It is known that PR transcriptional activity is paradoxically coupled to its ligand-dependent down-regulation. However, despite its importance in PR function, the regulation of SRC-1 expression level during hormonal exposure is poorly u...

Monoclonal antibodies (MAhs). recently produced against human progesterone receptors (PR), were used for immunocytochemical local ization of PR. The specificity of the immunocytochemical assay for PR was demonstrated by incubation with control M Mis. preabsorption of M Alis with highly purified human PR, and by the cell and tissue distribution of the immunostaining reaction. With human breast c...

The features and regulation of uterine angiogenesis and vascular remodelling during pregnancy are poorly defined. Here we show that dynamic and variable decidual angiogenesis (sprouting, intussusception and networking), and active vigorous vascular remodelling such as enlargement and elongation of 'vascular sinus folding' (VSF) and mural cell drop-out occur distinctly in a spatiotemporal manner...

Decidualization is a biological and morphological process occurring in hES (human endometrial stromal) cells. Previously, we reported that PLD1 (phospholipase D1) plays an important role in cAMP-induced decidualization of hES cells. In the present study, we focused on how PLD1 expression is up-regulated during decidualization. Treatment with PKA (protein kinase A) inhibitors (Rp-cAMP or H89) or...

DEAD-box proteins comprise a large protein family with members from all kingdoms and play important roles in all types of processes in RNA metabolism. In this study, a rice gene OsBIRH1, which encodes a DEAD-box RNA helicase protein, was cloned and characterized. The predicted OsBIRH1 protein contains a DEAD domain and all conserved motifs that are common characteristics of DEAD-box RNA helicas...