BACKGROUND New therapeutic approaches, particularly anti-vascular endothelial growth factor (anti-VEGF) therapies, prevent, and in some cases reverse, vision damage caused by age-related macular degeneration (AMD). Unequal access to care across Canada remains a problem for many retina specialists and their patients. OBJECTIVE To develop a consensus concerning the management of patients with e...

background: age-related macular degeneration (amd) is the leading cause of visual impairment and blindness in elderly population in the developing countries. previous epidemiological studies revealed various potential modifiable risk factors for this disease. the purpose of this study was to evaluate the prevalence of amd among elderly living in babol, north of iran.  methods:  the study popula...

BACKGROUND Drusen are important risk factor for neovascular age-related macular degeneration (AMD) and have a dynamic nature as they can enlarge, newly form, or disappear over time. There have been few reports on drusen regression or choroidal neovascularization (CNV) development after macular hole surgery. We report, to our knowledge, the first case of both drusen regression and subsequent CNV...

Many lines of evidence point to oxidative stress as a key pathogenic factor in age-related macular degeneration (AMD); the modestly positive results of the AREDS1 study – which evaluated supplemental zinc, vitamin E, vitamin C, and beta carotene in AMD patients provide confirmation for this view, while also pointing to a potential role for nutraceuticals in prevention and management of this syn...

PURPOSE Biochemical analysis of age-related macular degeneration (AMD) at distinct stages of the disease will help further understanding of the molecular events associated with disease progression. This study was conducted to determine the ability of a new grading system for eye bank eyes, the Minnesota Grading System (MGS), to discern distinct stages of AMD so that retinal region-specific chan...

BACKGROUND Utility of visual impairment caused by amblyopia is important for the cost-effectiveness of screening for amblyopia (lazy eye, prevalence 3-3.5 %). We previously measured decrease of utility in 35-year-old persons with unilateral persistent amblyopia. The current observational case-control study aimed to measure loss of utility in patients with amblyopia with recent decrease of visio...

PURPOSE Mitochondrial DNA (mtDNA) damage may be associated with age-related diseases, such as age-related macular degeneration (AMD). The present study was designed to test whether the frequency of mtDNA damage, heteroplasmic mtDNA mutations, and repair capacity correlate with progression of AMD. METHODS Macular and peripheral RPE cells were isolated and cultured from human donor eyes with an...

Age-related macular degeneration (AMD) is related to central visual loss in elderly people and, based on the increment percentage of aging population, number suffering from AMD could increase. initiated by retinal pigment epithelium (RPE) cell death, finally leading neovascularization macula lutea. an uncurable disease, but symptom can be suppressed. The current therapy classified into four typ...

Age-related macular degeneration (AMD) is a complex, progressive degenerative retinal disease. Retinal pigment epithelial (RPE) cells play an important role in the immune defense of eye and their dysfunction leads to irreversible photoreceptors. Genetic factors, chronic inflammation, oxidative stress have been implicated AMD pathogenesis. Oxidative causes RPE injury, resulting inflammatory resp...