The movement of the penetrant and polymer fronts and the drug dissolution in highly loaded swellable matrix tablets were studied with the aim of establishing relationships between front position and drug release kinetics. Three boundaries were identified corresponding to the swelling, diffusion and erosion fronts. The kinetics of drug release depended on the relative movement of the erosion and...

A novel enzyme-responsive hydrogel drug delivery system was developed with the potential to treat inflammation locally. Human neutrophil elastase (HNE) is a serine protease secreted by neutrophils which are the first cells recruited to inflammatory sites. We exploited this cell-secreted enzyme as a biological cue for controlled release. HNE sensitive peptide linkers were immobilized within poly...

In this study, the effects of various hydrophilic (HPMC and Carbopol 971) and plastic (Ethylcellulose and Eudragit RL100) polymers on the release profile of diltiazem HCl from matrix tablets were evaluated in-vitro. For this purpose, tablets containing 60 mg of diltiazem HCl along with various amounts of the aforementioned polymers were prepared using the wet granulation technique. Tablets prep...

In situ drug and organic electrolyte complex tablets were investigated as extended release dosage forms. Incorporating a 1:1 molar ratio of diltiazem HCl and an anionic organic electrolyte (i.e., Na deoxycholate) into HPC tablets extended the total release time with a near zero – order release rate (release exponent, n = 0.85 – 0.97) due to in situ complex formation of the drug and the organic ...

Coatings are a cheap and efficient solution to protect underlying metallic substrates against electrochemical corrosion. High performance coatings do not only provide this protection of the substrate in the undamaged state but also when they are scratched. This enhanced protection can be achieved in many different ways (ranging from primers based on expansive phases which seal the crack upon sc...

Hydrogel based tablets of Simvastatin was formulated using hydropropyl methyl cellulose(different grades), guar gum and carbopal-934-P with the aim to study of release kinetic, to attain a near zero order release and to increase the bioavalability upto 95%. In-vitro dissolution studies were carried out using USP type 2 dissolution test apparatus. The release of drug followed a typical Higuchian...

today hydrogels are considered as the materials that are able to play important role in drug delivery systems. to design an effective hydrogel applicable network, mathematical modeling has a critical role. a successful drug delivery device relies not only on intelligent network design but also on accurate prior mathematical modeling of drug release profiles. in this study, the modeling of the i...

On-chip sample preparation is essential for an easy, robust and accurate operation of point-of-care (POC) diagnostic devices. We recently demonstrated a simple cell-counting device realised by controlled antibody release from a gelatine layer implemented on a microfluidic chip. However, little is known about the release kinetics from this gelatine layer with sub-micrometre(μm)-scale thickness. ...

Affinity-based controlled release modulates the delivery of protein or small molecule therapeutics through transient dissociation/association. To understand which parameters can be used to tune release, we used a mathematical model based on simple binding kinetics. A comprehensive asymptotic analysis revealed three characteristic regimes for therapeutic release from affinity-based systems. Thes...

Preparation of matrix tablets with rate controlling polymers is the simplest and most widely used method for achieving desired controlled release rate of drugs. The objective of the present study was to evaluate the effect of concentration and particle size of Ethocel Premium 100P and 100FP and also the co-excipients like HPMC, starch and CMC on the release kinetics of Tramadol HCl from matrix ...