BACKGROUND Leptin has recently been shown to have a stimulatory effect on basal GH secretion. However, the mechanisms by which leptin exert this effect are not yet clear. GHRH and GH-releasing peptide (GHRP)-6 are the two most potent GH secretagogues described to date. OBJECTIVE To determine if leptin could also enhance in vivo GH responses to a maximal dose of GHRH. DESIGN Leptin (10microg...

Gonadotropin-releasing hormone (GnRH) is a neuropeptide hormone responsible for the release of luteinizing hormone (Lh) and follicle-stimulating hormone (Fsh) from the anterior pituitary gland . GnRH have been identified and characterized from the brain of C. catla. A cDNA fragment of 202bp was amplified and GnRH variant has been identified in the form chicken-II-type gonadotropin-releasing hor...

The aim of this study, comprising 88 suicide attempters, was to identify hypothalamic-pituitary-adrenal (HPA) -axis coupled CpG-sites showing methylation shifts linked to severity of the suicide attempt. Candidate methylation loci were further investigated as risk loci for a general psychiatric risk score in two cohorts of adolescents (cohort 1 and 2). The genome-wide methylation pattern was me...

In their review article, Drs. Crawford and Moul seek to describe the cardiovascular (CV), renal, and pulmonary complications associated with the use of long-term androgen deprivation therapy (ADT) in men with prostate cancer.[1] Furthermore, they attempt to determine whether there is a difference in CV and renal complications between different types of ADT, including luteinizing hormone–releasi...

The spontaneous secretion of growth hormone during a 24 hour period and the response of growth hormone to growth hormone releasing hormone was studied in 13 girls who had received treatment for acute lymphoblastic leukemia that included cranial irradiation with 20-24 Gy in 12-14 fractions. At the time of investigation the girls were at varying stages of puberty and had normal concentrations of ...

Introduction: Headache is one of the essential symptoms pituitary adenoma associated with tumor and patient’s characteristics. The pattern adenoma-related headaches varies widely can significantly impact quality life. Objectives: We aimed to investigate severity in patients Iran. Patients Methods: In this cross-sectional study, we investigated 109 an initial complement headaches. diagnosis was ...