The kidney has a high energy demand and is dependent on oxidative metabolism for ATP production. Accordingly, the kidney is rich in mitochondria, and mitochondrial dysfunction is a common denominator for several renal diseases. While the mitochondrial master regulator peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is highly expressed in kidney, its role in renal physiology...

Abstract Introduction Apelin is a vasoactive peptide isolated as a selective endogenous ligand of orphan receptor, APJ, which was genetically identified to have closest identity to the angiotensin II type 1 (AT-1) receptor. Subsequent studies elucidated the roles of the apelin–APJ system in human physiology, including the regulation of cardiovascular function and fluid homeostasis. In spite of ...

Renal function plays a central role in cardiovascular, kidney, and multiple other diseases, and many existing and novel therapies act through renal mechanisms. Even with decades of accumulated knowledge of renal physiology, pathophysiology, and pharmacology, the dynamics of renal function remain difficult to understand and predict, often resulting in unexpected or counterintuitive therapy respo...

As part of the Basic Science Survey Series for Dentistry, members of the American Dental Education Association (ADEA) Physiology, Pharmacology, and Therapeutics Section surveyed directors of physiology courses in North American dental schools. The survey was designed to assess, among other things, faculty affiliation and experience of course directors, teaching methods, general course content a...

Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of 4 Medicine, University of Alabama at Birmingham, Birmingham, AL 5 6 7 8 Corresponding Author: Jennifer S. Pollock, PhD 9 Section of Cardio-Renal Physiology and Medicine 10 Division of Nephrology 11 Department of Medicine 12 University of Alabama at Birmingham 13 720 20 Street S, Kaul 802A 14 Birmingham, AL 35...

The purpose of this paper is to note the importance ?f Richard Bright's Reports of Medical Cases1 for renal physiology, and to ask what the Reports may teach us about the relation between physiology and clinical medicine not only in its own time but also to-day, a century and a half after publication. The greater part and central matter of the Reports are descriptions of twenty-three cases of r...

The purpose of this study was to determine whether, in comparison with naive students, experienced students who have completed an elementary physiology course 1) have a greater knowledge level of physiology and 2) perform better in an upper division physiology course. The educational setting for this study was the cardiovascular block of an advanced undergraduate level course entitled Principle...

In the teaching of Exercise Physiology, ideological and political elements are integrated, reform Physiology is implemented for purpose building content course strengthening moral education students. Combined with characteristics students, teaching, other aspects analysis, innovation was made in design cases, cases were integrated into teaching. The elements, aiming to improve values college st...