BACKGROUND Rosuvastatine, doxazosin, repaglinide and oxcarbazepin are therapeutic drugs available in the market for the treatment of different diseases. Potential to display antitumor activities has also been suggested. The aim of the current study was to evaluate their in vitro effects on some human transformed cell lines. MATERIALS AND METHODS Cytotoxicity of the four drugs was tested in MC...

Aim: The aim of the present investigation was to design a proliposomal gel system of Repaglinide for the treatment of type 2 diabetes mellitus that is capable of delivering entrapped drug over an extended period of time. Method: Proliposomes of Repaglinide were prepared by thin film hydration technique by varying the composition mannitol, soya lecithin and cholesterol. Proliposome formulations ...

AIMS/INTRODUCTION The aim of the present study was to evaluate the long-term efficacy and safety of adding repaglinide in patients with type 2 diabetes mellitus whose blood glucose levels were not sufficiently controlled by treatment with a dipeptidyl peptidase-4 inhibitor, sitagliptin, in addition to diet and exercise therapies. MATERIALS AND METHODS This was a multicenter, uncontrolled, dos...

Gemfibrozil has been suggested as a sensitive cytochrome P450 2C8 (CYP2C8) inhibitor for clinical investigation by the U.S. Food and Drug Administration and the European Medicines Agency. However, gemfibrozil drug-drug interactions (DDIs) are complex; its major circulating metabolite, gemfibrozil 1-O-b-glucuronide (GemGlu), exhibits time-dependent inhibition of CYP2C8, and both parent and metab...

Deregulated protein and Ca2+ homeostasis underlie synaptic dysfunction and neurodegeneration in Huntington disease (HD); however, the factors that disrupt homeostasis are not fully understood. Here, we determined that expression of downstream regulatory element antagonist modulator (DREAM), a multifunctional Ca2+-binding protein, is reduced in murine in vivo and in vitro HD models and in HD pat...