Epigenetic regulation of chromatin and the DNA damage response are now well appreciated key players in human aging. What contributions chromatin and DAN repair make to aging, whether they are causal, and how these relate to other aging pathways, however, is unclear. Novel insights into the aging-related molecular mechanisms that link chromatin and DNA damage repair have recently been gained by ...

I n the past many decades, breakdown, maintenance and replacement issues of deteriorating machines and systems are extensively studied within the literature. A number of maintenance and replacement models, techniques and policies are created, documented and tested. However, of these models are comprised of some classes ∗M.Tech. Student, Department of Mechanical Engineering, Madhav Institute of ...

This paper proposes a maintenance platform for business vehicles which detects failure sign using IoT data on the move, orders to create repair parts by 3D printers and to deliver them to the destination. Recently, IoT and 3D printer technologies have been progressed and application cases to manufacturing and maintenance have been increased. Especially in air flight industry, various sensing da...

According to the characteristics and application of 3D printing technology, problems be faced in process equipment maintenance rush repair are analyzed, advantages technology for summarized. Moreover, phenomenon analysis, finite element analysis optimization carried out combination with vulnerable parts large engineering equipment. To provide data samples based on FDM repair, explore potential ...

This paper presents a method to find the optimal production, repair/replacement and preventive maintenance policies for a degraded manufacturing system. The system is subject to random machine failures and repairs. The status of the system is deemed to degrade with repair activities. When a failure occurs, the machine is either repaired or replaced, and a replacement action renews the machine, ...

— This paper deals with the availabiïity and reliability analysis of a 2-unit System with two service facilities-one for préventive maintenance and the other for repair. The times to failure and préventive maintenance of a unit are assumed to be arbitrariîy distributed whüe the times for repair and préventive maintenance are exponentially distributed. The Laplace transforms ofthe mean down-time...

In the existing approach to maintenance and repair decision making for infrastructure facilities, policy evaluation and policy selection are performed under the assumption that a perfect facility deterioration model is available. The writer formulates the problem of developing maintenance and repair policies as a reinforcement learning problem in order to address this limitation. The writer exp...

An operating system is observed to undergo failures. On failure, one of three actions was taken: failures were minimally repaired, given a minor repair or given a major repair. Furthermore, periodically the machine was stopped for either minor maintenance action or major maintenance action. Either on failure or maintenance stoppage, both minor and major repairs are assumed to impact the failure...

The defense sector represents one of the largest potential areas for new ERP sales. Many defense organizations have already implemented ERP solutions to manage and integrate the acquisition, maintenance, and support processes. This paper addresses specifically the defense maintenance management functions that need to be integrated into an ERP solution by adopting the view of a defense repair an...

warranty as a kind of service contract today plays a role key in business and legal transactions. in this paper, we present a manufacturer, an agent and a customer's model under different service contracts suggestions. the manufacturer's profit is maximized by determining sale price, warranty period and warranty price. in addition we obtain optimal maintenance cost or repair cost for ...