Background: Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by the expansion of HTT CAG repeat. Affected individuals inherit ?36 repeats and longer alleles cause earlier onset, greater severity faster progression. The repeat genetically unstable in soma a process that preferentially generates somatic expansions, proportion which associated with Somatic mosai...

Repeat proteins have become increasingly important due to their capability to bind to almost any proteins and the potential as alternative therapy to monoclonal antibodies. In the past decade repeat proteins have been designed to mediate specific protein-protein interactions. The tetratricopeptide and ankyrin repeat proteins are two classes of helical repeat proteins that form different binding...