seizures are the most common disorder of the central nervous system in childhood and constitute a significant number of admissions to the pediatric emergency departments. the aim of this study is evaluate the etiology of hypocalcemic seizures in pediatrics. a single-center, hospital based descriptive study was done in the academic referral center for hypocalcemic seizure of tehran university of...

OBJECTIVES To quantify the relationship between exposure to lacosamide monotherapy and seizure probability, and to simulate the effect of changing the dose regimen. METHODS Structural time-to-event models for dropouts (not because of a lack of efficacy) and seizures were developed using data from 883 adult patients newly diagnosed with epilepsy and experiencing focal or generalized tonic-clon...

BACKGROUND & OBJECTIVES Hot water epilepsy (HWE) is well recognized reflex epilepsy with possible genetic susceptibility. Rat model and human experimentation had proven that HWE is a type of hyperthermic seizure with possible kindling on repeated stimulation in animals. The present study was undertaken to investigate kindling associated with hyperthermic seizures induced by repeated hot water s...

PURPOSE To determine whether repeated seizures contribute to hippocampal sclerosis, we investigated whether cell loss in the (para) hippocampal region was related to the severity of chronic seizure activity in a rat model for temporal lobe epilepsy (TLE). METHODS Chronic epilepsy developed after status epilepticus (SE) that was electrically induced 3-5 months before. The presence of neuronal ...

SECTION 1 A previously healthy 35-year-old Sudanese woman was admitted with new-onset right hemispheric seizures with secondary generalization. The patient’s vital signs were temperature 100.2°F, blood pressure 133/96 mm Hg, pulse 83 beats per minute, respirations 18 per minute, and oxygen saturation 100% on room air. Additionally, a complete neurologic examination was within normal limits. She...

Alterations of norepinephrine transporter (NET) function by chronic inhibition of NET in relation to sensitization to seizures induce by cocaine and local anesthetics were studied in mice. Daily administration of desipramine, an inhibitor of the NET, for 5 days decreased [(3)H]norepinephrine uptake in the P2 fractions of hippocampus but not cortex, striatum or amygdalae. Co-administration of li...

PURPOSE It is unclear why some children with falciparum malaria develop acute seizures and what determines the phenotype of seizures. We sought to determine if polymorphisms of malaria candidate genes are associated with acute seizures. METHODS Logistic regression was used to investigate genetic associations with malaria-associated seizures (MAS) and complex MAS (repetitive, prolonged, or foc...

CMYK 523 Figure 2: Plain and contrast CT scan of the brain done on 09/11/2003 shows a left fronto-parietal hypodense, extracerebral fluid collection with severe brain edema causing midline shift and obliteration of the basal cistern Sir, Periodic lateralized epileptiform discharges (PLEDs) are a well-defined electroencephalographic entity known for the past four decades. PLEDs have been associa...

Single-electrode voltage-clamp techniques and bath application of the N-methyl-D-aspartate (NMDA) receptor antagonist 2-amino-5-phosphonovaleric acid (APV) were used to study the time course of seizure-induced alterations in NMDA-dependent synaptic currents in granule cells of the dentate gyrus in hippocampal slices from kindled and normal rats. In agreement with previous studies, granule cells...

In the present study, we compared the expression patterns of neuritin mRNA in the dentate gyrus of hippocampal formation following single (1×ECS) or repeated elctroconvulsive seizures (8×ECS) treatments to the rat. The expression of neuritin mRNA was transiently increased, and returned to basal level within 12 hours after 1×ECS. Whereas initial induction of neuritin mRNA was similarly seen, the...