نتایج جستجو برای: reperfusion oxidant

تعداد نتایج: 50938  

Journal: :Cardiovascular research 2004
Hajime Kin Zhi-Qing Zhao He-Ying Sun Ning-Ping Wang Joel S Corvera Michael E Halkos Faraz Kerendi Robert A Guyton Jakob Vinten-Johansen

OBJECTIVE We previously showed that brief intermittent ischemia applied during the onset of reperfusion (i.e., postconditioning) is cardioprotective in a canine model of ischemia-reperfusion. This study tested the hypothesis that the early minutes of reperfusion (R) during which postconditioning (Post-con) is applied are critical to its cardioprotection. METHODS In anesthetized open-chest rat...

Journal: :Stroke 2011
Rong Jin Zifang Song Shiyong Yu Abigail Piazza Anil Nanda Josef M Penninger D Neil Granger Guohong Li

BACKGROUND AND PURPOSE Phosphoinositide 3-kinase (PI3K)-γ is linked to inflammation and oxidative stress. This study was conducted to investigate the role of the PI3Kγ in the blood-brain barrier dysfunction and brain damage induced by focal cerebral ischemia/reperfusion. METHODS Wild-type and PI3Kγ knockout mice were subjected to middle cerebral artery occlusion (60 minutes) followed by reper...

2017
Hong Chen Gang Chen Claire Condron

Purpose: Gut permeability and microvascular injury following ischaemia/reperfusion (IR) have been implicated in the systemic inflammatory response syndrome (SIRS) and multiple organ failure (MOF). Taurine (TAU), a sulfurcontaining amino acid, is a powerful antioxidant and regulator of intracellular calcium and several studies have established that treatment with TAU protects cerebral, cardiac a...

Journal: :Journal of cardiovascular pharmacology 2005
Avi A Weinbroum

Liver ischemia and subsequent reperfusion (IR) are associated with secondary, remote organ reperfusion injury attributable to oxidative stress mediators. Because N-acetyl-L-cysteine (NAC) was effective in attenuating lung reperfusion injury, its properties on aortic dysfunction were tested. Rat isolated perfused aortic rings (n = 8/group) were evaluated during and after exposure to liver postis...

Journal: :Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2014
Jung-Woo Kang Hong-Ik Cho Sun-Mee Lee

BACKGROUND Autophagy is a self-digestion system responsible for maintaining cellular homeostasis and interacts with reactive oxygen species produced during ischemia/reperfusion (I/R). Melatonin (MLT) is a potent and endogenous anti-oxidant that has beneficial effects in liver I/R injury. In this study, we examined the cytoprotective mechanisms of MLT in liver I/R, focusing on autophagic flux an...

Journal: :Free radical research 2006
Lorenza Tacchini Gaetano Cairo Cristina De Ponti Marta Massip Joan Rosellò-Catafau Carmen Peralta

We analyzed the role of IL-6 in the protection that ischemic preconditioning (IP) exerts against hepatic ischemia reperfusion-mediated (I/R) oxidative damage, particularly in fatty livers. IP-related IL-6 up-regulation during reperfusion in steatotic and non-steatotic livers was correlated with reduced indices of liver damage, as also demonstrated by pharmacological modulation of IL-6. IP activ...

Journal: :Scientific reports 2016
Sana Khalid Astrid Drasche Marco Thurner Martin Hermann Muhammad Imtiaz Ashraf Friedrich Fresser Gottfried Baier Leopold Kremser Herbert Lindner Jakob Troppmair

p66Shc-dependent ROS production contributes to many pathologies including ischemia/reperfusion injury (IRI) during solid organ transplantation. Inhibiting p66Shc activation may provide a novel therapeutic approach to prevent damage, which is poorly managed by antioxidants in vivo. Previous work suggested that pro-oxidant and a pro-apoptotic function of p66Shc required mitochondrial import, whic...

Journal: :American journal of physiology. Heart and circulatory physiology 2004
Peitan Liu Baohuan Xu Thomas A Cavalieri Carl E Hock

Mortality due to ischemic cardiovascular diseases is significantly higher in elderly than in young adults. Myocardial ischemia-reperfusion (MI/R) can induce oxidative stress and an inflammatory response. We hypothesized that increased vulnerability of aged myocardium to reperfusion injury could be caused by decreased antioxidative capacity, rather than increased oxidant production, after MI/R. ...

2015
Mustafa Ozsoy Yucel Gonul Ahmet Bal Ziya Taner Ozkececi Ruchan Bahadir Celep Fahri Adali Omer Hazman Ahmet Koçak Murat Tosun

PURPOSE Severe local and systemic tissue damage called ischemia/reperfusion (IR) injury occurs during the period of reperfusion. Free oxygen radicals and proinflammatory cytokines are responsible for reperfusion injury. IL-18 binding protein (IL-18BP) is a natural inhibitor of IL-18. The balance between IL-18 and IL-18BP has an important role in the inflammatory setting. The present study aimed...

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