AIMS To determine the incremental cost effectiveness of nicotine replacement therapy (NRT), bupropion and varenicline for preventing relapse to smoking when used by abstinent smokers DESIGN SETTING AND PARTICIPANTS Cohort simulation and sensitivity analyses combining cost and health service data with systematic review estimates for the effectiveness of NRT, bupropion and varenicline when used...

    Background: Economic evaluation of subcutaneous immunoglobulin therapy (SCIG) is important, and it has recently been used for treatment of patients with primary immunodeficiency (PID) diseases, and can improve allocation of resources in health care systems. The present research aimed at providing an economic assessment of SCIG and IVIG (intravenous immunoglobulin therapy) adm...

Traditional approaches for solving the molecular replacement problem separate a six-dimensional optimization problem into two three-dimensional ones in order to reduce the computational cost. There are, however, serious drawbacks in such a separation of the rotational and translational degrees of freedom. In this paper, we present computational experiments indicating that even under ideal condi...

As part of a large retrospective study of the durability and lifespan of 2229 restorations (1898 amalgams and 331 stainless steel crowns) in primary molars of 226 pediatric patients attending a dental school clinic, the costs associated with first placement and later replacements of the restorations were examined. Individual restoration histories were followed for up to 9 years, computerized, a...

A predictive-maintenance structure for a gradually deteriorating single-unit system (continuous time/continuous state) is presented in this paper. The proposed decision model enables optimal inspection and replacement decision in order to balance the cost engaged by failure and unavailability on an infinite horizon. Two maintenance decision variables are considered: the preventive replacement t...