In order to better understand the role of glucocorticoid receptor in the hormonal action of glucocorticoid, depletion and replenishment of the cytoplasmic receptor and kinetics of induction of tyrosine aminotransferase (TAT) in rat liver were examined after administration of dexamethasone (Dex) and prednisolone. The extent of the receptor depletion and the duration of the depletion period were ...

This paper considers the joint supplier selection, replenishment and manufacturing control problem in a dynamic stochastic context. This problem is characterized by conflicting interests between suppliers, the manufacturer, and clients, which raise the need for coordination and information sharing. This paper contributes to the discourse mainly by developing and resolving an integrated mathemat...

Synaptotagmin (syt) 7 is one of three syt isoforms found in all metazoans; it is ubiquitously expressed, yet its function in neurons remains obscure. Here, we resolved Ca(2+)-dependent and Ca(2+)-independent synaptic vesicle (SV) replenishment pathways, and found that syt 7 plays a selective and critical role in the Ca(2+)-dependent pathway. Mutations that disrupt Ca(2+)-binding to syt 7 abolis...

This research investigates the impact of electronic replenishment strategy on the operational activities and performance of a two-stage make-to-order supply chain. We develop simulation-based rolling schedule procedures that link the replenishment processes of the channel members and apply them in an experimental analysis to study manual, semi-automated, and fully automated e-replenishment stra...

Supply chain coordination has received substantial attention in the operations literature in recent years. Coordination issues in supply chains arise due to several factors, an important one being the difference in the cost impact of inventory and replenishment decisions on the manufacturer and retailer. In this paper, we address this asymmetry in cost impact that can lead to sub-optimal channe...

A joint replenishment problem is presented to determine the ordering policy for multiple items having a certain percentage of defective units. The purpose of this paper is to study the impact of the percentage of defective units on the ordering policy. Two different scenarios are presented for joint replenishment problem: (1) without price discount and (2) with price discount. For each scenario...

Abstract: This study is concerned with replenishment decision making with repairable nonconforming products, backordering and random equipment failure during production uptime. In real world manufacturing systems, due to different factors generation of nonconforming items and unexpected machine breakdown are inevitable. Also, in certain business environments various situations between vendor an...

The risks on supply chain have increased continuously in recent years. One such risk for Hi-tech products is the result of rapid technological innovation which results in a significant decline in the component cost, the selling price and the demand (due to newer products introduction). The Hi-tech products include computers and communication consumer’s products. From a practical standpoint, a m...

This paper is motivated by inventory problems arising in supply chains characterized by continuous replenishment programs based on information exchanged (reviewed) only intermittently between a manufacturing system (supplier) and a customer (retailer). When the replenishment is once-per-period, rather than at any point of time, a well-known result is the optimality of the so-called myopic base-...

In the supply chain management, the supplier can reduce its total cost by providing price discounts to restrict the retailers’ replenishment intervals to multiples of a common replenishment interval. In order to accomplish this purpose, supplier often determined a price discount that all the retailers can accept. After the cost of the supplier was further considered, a better price discount was...