نتایج جستجو برای: repolarization

تعداد نتایج: 5285  

Journal: :Cardiovascular research 2007
Ruben Coronel Tobias Opthof Alexei N Plotnikov Francien J G Wilms-Schopman Iryna N Shlapakova Peter Danilo Eugene A Sosunov Evgeny P Anyukhovsky Michiel J Janse Michael R Rosen

OBJECTIVE The contribution of regional electrophysiologic heterogeneity to the T-wave changes of long-term cardiac memory (CM) is not known. We mapped activation and repolarization in dogs after induction of CM and in sham animals. METHODS AND RESULTS CM was induced by three weeks of AV-sequential pacing at the anterior free wall of the left ventricle (LV), midway between apex and base in 5 d...

Journal: :Cardiovascular research 2013
Emmanuel Moss René Cardinal Yalin Yin Pierre Pagé

AIMS Given the clinical interest concerning 'reflex vagal' responses to identify left atrial (LA) targets for ablative therapy of atrial fibrillation, we investigated whether vagal and bilateral atrial neural pathways may be involved in chronotropic and atrial repolarization responses to LA ganglionated plexus (GP) stimulation. METHODS AND RESULTS Unipolar electrograms were recorded from 191 ...

Journal: :Circulation research 1972
T Sano T Sawanobori

The false tendon was isolated from the dog heart and mounted under a partition plate in the center of a chamber which was filled with Tyrode's solution. Two microelectrodes were positioned closely on either side of the plate and inserted into the false tendon. The partition did not alter repolarization of the action potential in normal Tyrode's solution. When EDTA was added to one side of the p...

Journal: :Cardiology journal 2009
Aimé Bonny Ivo Ditah Walid Amara Brahim Hamdaoui Robert Frank Jean-Yves Le Heuzey

Until recently it was generally thought that early repolarization is benign. But a recent article in the NEJM (Haissaguerre et al.) suggests that some persons with early repolarization may be at risk of life-threatening ventricular tachyarrhythmia. Unexplained syncope or sudden death occurs mostly during sleep. However, some cases of cardiac arrest during exertion have been reported. We report ...

2012
Attila Kristóf Zoltán Husti István Koncz Zsófia Kohajda Tamás Szél Viktor Juhász Péter Biliczki Norbert Jost István Baczkó Julius Gy Papp András Varró László Virág

BACKGROUND The aim of the present work was to characterize the electrophysiological effects of the non-steroidal anti-inflammatory drug diclofenac and to study the possible proarrhythmic potency of the drug in ventricular muscle. METHODS Ion currents were recorded using voltage clamp technique in canine single ventricular cells and action potentials were obtained from canine ventricular prepa...

2014
Chun-An Chen Meng-Yao Lu Shinn-Forng Peng Kai-Hsin Lin Hsiu-Hao Chang Yung-Li Yang Shiann-Tarng Jou Dong-Tsamn Lin Yen-Bin Liu Herng-Er Horng Hong-Chang Yang Jou-Kou Wang Mei-Hwan Wu Chau-Chung Wu

BACKGROUND Patients with transfusion-dependent beta-thalassemia major (TM) are at risk for myocardial iron overload and cardiac complications. Spatial repolarization heterogeneity is known to be elevated in patients with certain cardiac diseases, but little is known in TM patients. The purpose of this study was to evaluate spatial repolarization heterogeneity in patients with TM, and to investi...

Journal: :Circulation 2011
Daisuke Haruta Kiyotaka Matsuo Akira Tsuneto Shinichiro Ichimaru Ayumi Hida Nobuko Sera Misa Imaizumi Eiji Nakashima Koji Maemura Masazumi Akahoshi

BACKGROUND Early repolarization pattern is a common ECG finding characterized by J-point elevation and QRS notching or slurring in the inferior and/or lateral leads, yet little is known about its incidence and long-term prognosis in Asian populations. METHODS AND RESULTS We reviewed all the ECG records of the 5976 atomic-bomb survivors who were examined at least once during our biennial healt...

2005
MICHAEL R. FRANZ

T wave concordance in the normal human electrocardiogram (ECG) generally is explained by assuming opposite directions of ventricular depolarization and repolarization; however, direct experimental evidence for this hypothesis is lacking. We used a contact electrode catheter to record monophasic action potentials (MAPs) from 54 left ventricular endocardial sites during cardiac catheterization (s...

Journal: :Cell 2005
Danny L. Costantini Eric P. Arruda Pooja Agarwal Kyoung-Han Kim Yonghong Zhu Wei Zhu Melanie Lebel Chi Wa Cheng Chong Y. Park Stephanie A. Pierce Alejandra Guerchicoff Guido D. Pollevick Toby Y. Chan M. Golam Kabir Shuk Han Cheng Mansoor Husain Charles Antzelevitch Deepak Srivastava Gil J. Gross Chi-chung Hui Peter H. Backx Benoit G. Bruneau

Rhythmic cardiac contractions depend on the organized propagation of depolarizing and repolarizing wavefronts. Repolarization is spatially heterogeneous and depends largely on gradients of potassium currents. Gradient disruption in heart disease may underlie susceptibility to fatal arrhythmias, but it is not known how this gradient is established. We show that, in mice lacking the homeodomain t...

Journal: :American journal of physiology. Heart and circulatory physiology 2009
Mark Potse Alain Vinet Tobias Opthof Ruben Coronel

Local unipolar electrograms (UEGs) permit assessment of local activation and repolarization times at multiple sites simultaneously. However, UEG-based indexes of local repolarization are still debated, in particular for positive T waves. Previous experimental and computer modeling studies have not been able to terminate the debate. In this study we validate a simple theoretical model of the UEG...

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