Multidrug-resistant (MDR) Klebsiella pneumoniae may require combination therapy. We systematically investigated bacterial killing with colistin and doripenem mono- and combination therapy against MDR K. pneumoniae and emergence of colistin resistance. A one-compartment in vitro pharmacokinetic/pharmacodynamic model was employed over a 72-h period with two inocula (∼10(6) and ∼10(8) CFU/ml); a c...

background:the bacterial contamination of fertile eggs isthe most common cause of embryonic death in ostrich hatcheryunits leading to financial loss in ostrich industry. objectives:the aim of this research was to investigate the bacterialcontamination status, with emphasis on escherichia coli, ofostrich hatcheries and the antimicrobial resistance profile ofisolated escherichia coli. methods:ato...

BACKGROUND Bacterial pathogens isolated from dacryocystitis patients are diverse and complex in terms of their distribution, prevalence, and antimicrobial susceptibility pattern. The clinical importance of microbial causes of dacryocystitis and pattern of drug resistance has not been reported in northwest Ethiopia. Moreover, the management of dacryocystitis is based on only clinical observation...

Green synthesis of metal nanoparticles (NPs) from plant extracts has attracted significant interest in modern medicine. Therefore, this study prepared an aqueous extract Sophora flavescens roots, which are used folk medicine to treat several diseases, including bacterial infections. In addition, silver NPs (AgNPs) were synthesized root using the green method. The diagnosed methods. Additionally...

Extended Spectrum â-lactamase (ESBL) producing multidrug resistant bacteria complicate therapeutic management and limit treatment options. Therefore, detection of ESBL-producing multidrug resistant (MDR) pathogens has a paramount importance. Between April 2009 and January 2010, a prospective study was carried out in National Public Health Laboratory with an objective to determine the status of ...

BACKGROUND External and intraocular infections can lead to visual impairments, which is a major public health problem. Bacteria are the most frequent pathogens affecting ocular structures; the increasing rate of antimicrobial drug resistance is a worldwide concern. The aim of this study was to determine the occurrence of bacteria in ocular infections, their antimicrobial susceptibility patterns...

background nosocomial infections including infections of surgical wounds, urinary tract and lower respiratory tract infections are a major public health problem in hospitals worldwide. bacterial infections in the lower respiratory tract especially due to gram negative bacilli, has remained a major complication of tracheal intubation in patients requiring ventilator equipments. objectives the ai...

Multi-drug resistance has become a major problem for the treatment of pathogenic bacterial infections. The use of bacteriophages is an attractive approach to overcome the problem of drug resistance in several pathogens that cause fatal diseases. Our study aimed to isolate multi drug resistant bacteria from patients with septic wounds and then isolate and apply bacteriophages in vitro as alterna...

urinary tract infection (uti) is a common bacterial illness in children. knowledge of the antimicrobial resistance patterns of common uropathogens in children according to local epidemiology is essential for providing clinically appropriate, cost effective therapy for uti. the aim of this study was to determine the distribution of urinary tract infections in a referral hospital, children’s medi...

The heat tolerance of 27 Enterococcus faecium isolates in water was studied. Stationary phase cultures including vancomycin resistant and sensitive clinical and food isolates were exposed to heat at 60 degrees, 65 degrees, 71 degrees, and 80 degrees C for one, three, 10, and 30 minutes and the log10 reductions in bacterial counts were determined. Exposure at 71 degrees and 80 degrees C resulted...