Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) are increasingly causing infective endocarditis over the past decade. Here we report a healthy man who developed a severe acute infective endocarditis with systemic embolism caused by CA-MRSA. The strain was recovered from repeated blood cultures and was characterized using molecular detection and genotyping. The S. aure...

OBJECTIVES To compare extracellular and intracellular activities of telavancin (versus vancomycin) against Staphylococcus aureus (MSSA, MRSA, VISA and VRSA). METHODS Determination of cfu changes (3-24 h) in culture medium and in macrophages at concentrations ranging from 0.01 to 1000x MIC. RESULTS Extracellularly, telavancin displayed a fast, concentration-dependent bactericidal activity ag...

background quorum sensing is a microbial cell-to-cell communication process. quorum sensing bacteria produce and release extracellular messenger molecules called autoinducers. gram-positive and gram-negative, homoserine lactones, and oligopeptides are autoinducers used to communicate and regulate gene expression. objectives the goal of this study was to assess the impact of subinhibitory concen...

therapy without antibiotics. Finally, the hypothesis for MRSA being selected by the use of cefquinome in those horses cannot be excluded. In this study, two CCs with no geographical clustering were characterized. Indeed, three MRSA strains belonged to CC130, the most prevalent CC among mecC-positive MRSA in animals, whereas the fourth one belonged to ST49, which was recently described in mecC-p...

UNLABELLED ABSBACKGROUND: Since the detection of MRSA CC398 in pigs in 2004, it has emerged in livestock worldwide. MRSA CC398 has been found in people in contact with livestock and thus has become a public health issue. Data from a large-scale longitudinal study in two Danish and four Dutch pig herds were used to quantify MRSA CC398 transmission rates within pig herds and to identify factors a...

In The Netherlands a new reservoir of MRSA has recently been identified in pigs and veal calves upon which the 'Dutch Working Party on Infection Prevention' modified the national MRSA guidelines. In June 2006 a new group at risk of MRSA carriage was included, consisting of patients that reported direct exposure to living pigs or veal calves. After the implementation of this modification in a tr...

OBJECTIVES The emergence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has changed the epidemiology of MRSA infections worldwide. In contrast to hospital-associated MRSA (HA-MRSA), CA-MRSA more frequently affects healthy individuals, both with and without recent healthcare exposure. Despite obvious epidemiological differences, it is unknown whether differences in...

Staphylococcal cassette chromosome mec (SCCmec) types and Panton-Valentine leukocidin (PVL) gene carriage were compared among suspected community-associated methicillin-resistant Staphylococcus aureus MRSA (CA-MRSA) and health care-associated MRSA (HA-MRSA) isolates. CA-MRSA isolates carried the SCCmec type IV complex, and most were PVL positive. The HA-MRSA isolates carried the SCCmec type II ...

Staphylococcal infections are a group of infections caused by the bacterium Staphylococcus but most infections are caused by a type called Staphylococcus aureus. Bacteria are constantly evolving because their genes are constantly changing. The result of this is that some of the bacteria develop more resistance to a certain antibiotic than others. Methicillin-resistant Staphylococcus aureus is a...

Infections with Staphylococcus aureus with reduced susceptibility to vancomycin continue to be reported, including 2 cases caused by S. aureus isolates with full resistance to vancomycin. This review first outlines the definitions of vancomycinintermediate S. aureus (VISA) and vancomycin-resistant S. aureus (VRSA) and risk factors for infection. Next, we describe the mechanisms of resistance an...