The presence of hereditary protein C deficiency has been shown to predispose patients to the development of venous thrombosis. We used radioimmunoassays for the protein C activation peptide (PCP) and the prothrombin fragment F1 + 2 to quantitate the extent of in vivo activation of protein C by thrombin-thrombomodulin and prothrombin by factor Xa, respectively, in the blood of individuals with t...

BACKGROUND Salvage surgery after concomitant chemoradiation therapy (CCRT) for patients with head and neck squamous cell carcinomas (HNSCC) is challenging because of its associated morbidity/mortality and the poor prognoses of these patients. METHODS The outcome analysis of prospectively collected data from 93 patients with HNSCC with local and/or regional shows treatment failures but without...

background : in this study, the inhibitory effect of ethylene dichloride (edc) on biodegradation was investigated using the specific methanogenic activity (sma) test of anaerobic biomass. methods: in the present study, 40 sma tests were performed using 120-ml vials in batch mode. substrate, biomass, and biogas occupied 66%, 17%, and 17% (v/v) of the volume of each vial, respectively. the durati...

Chronic idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder in which the abnormality in cellular immunity has remained only vaguely defined. Previously we have shown that patients with ITP in its active phase have abnormal T cell subsets. We then examined the phenotypes of T and B lymphocytes in an additional 28 patients with ITP and 32 age- and sex-matched normal controls and c...

and the mean observed peak plasma metoprolol concentration by about 33%. Furthermore, the elimination half life of metoprolol was prolonged from 3-9 hours during monotreatment to 6-0 hours when ranitidine was given in combination (p<0005). There was no evidence that any of the volunteers were poor metabolisers of metoprolol. Beta-blockade was assessed on the sixth treatment day by examining the...

Serial nerve conduction velocities in the peroneal and ulnar nerves have been measured in 10 patients on regular dialysis treatment over a three year period. Each patient alternated between phases on dialysis with magnesium-containing dialysate (1·5-1·7 m-equiv/l.) and phases on `magnesium-free' dialysate (0·2 m-equiv/l.). Plasma magnesium concentrations were high both pre- and post-dialysis du...

INTRODUCTION AND OBJECTIVES Intracoronary ultrasound estimation of the functional significance of intermediate angiographic lesions has mainly been based on measuring the minimal lumen area. These estimates take no account of lesion length and pay insufficient attention to long coronary lesions. METHODS We included 61 lesions with visual angiographic stenosis of 40% to 70% that required treat...