Background: Tramadol, an analgesic drug abused by opioid addicts, is also abused accidentally or for suicidal purposes. Tramadol poisoning can induce CNS depression, seizures, coma, and ultimately death. Case: In this report, a 30-year-old male was admitted to the emergency department due to suicidal attempt with ingestion of 14000 mg (140 tablet 100 mg) of tramadol. He had history of suicidal...

Pathological neuronal inclusions of the 43-kDa TAR DNA-binding protein (TDP-43) are implicated in dementia and motor neuron disorders; however, the molecular mechanisms of the underlying cell loss remain poorly understood. Here we used a yeast model to elucidate cell death mechanisms upon expression of human TDP-43. TDP-43-expressing cells displayed markedly increased markers of oxidative stres...

BACKGROUND Respiratory complications were associated with half of pediatric malpractice claims from the 1970s to 1980s in the ASA Closed Claims Database. Advances in pediatric anesthesia practice have occurred in the 1980s and 1990s and may be reflected in liability trends. METHODS We reviewed 532 pediatric (age < or =16 yr) malpractice claims from our database over three decades (1973-2000),...

We present updated results from ASPIRO (NCT03199469), investigating gene replacement therapy with AT132 for XLMTM patients. XLMTM, an ultra-rare, life-threatening myopathy caused by variants in the MTM1 gene, leads to impaired neuromuscular and respiratory function, early death.

AIM To compare indices of respiratory failure in terms of their ability to predict adverse respiratory outcomes in preterm infants. The indices evaluated were: (a) the alveolar-arterial oxygen tension difference (A-aDO(2)); (b) the ratio of arterial to alveolar oxygen tension (a/A ratio); (c) the oxygenation index (OI); (d) the fractional inspired oxygen concentration (FIO(2)). METHODS Detail...

BACKGROUND Neurological respiratory insufficiency strongly correlates with mortality among rodents infected with West Nile virus (WNV), which suggests that this is a primary mechanism of death in rodents and possibly fatal West Nile neurological disease in human patients. METHODS To explore the possibility that neurological respiratory insufficiency is a broad mechanism of death in cases of v...

For decades, these kinds of reports have suggested that cardiac and infectious illnesses are the main causes of death in the developed and developing world, respectively. If respiratory illnesses, including pneumonia, TB, and cancer in the respiratory system, among others, were grouped separately, the sum would reach 17% of all deaths and would be the top cause of death in the world. The Year o...

OBJECTIVE This study explored the risk of respiratory cancer and non-malignant respiratory disease (NMRD)-related mortality among older construction workers. METHODS Analyzed data from the 1992-2010 RAND Health and Retirement Study (HRS) and the HRS National Death Index - Cause of Death file. About 25,183 workers aged 50 years and older were examined, including 5,447 decedents and 19,736 surv...

background: different measures of mortality and morbidity statistics is a good tool in determining the health status of a community،the health network development and application of methods of prevention and treatment. basis of mortality data is the death certificate and the most important index in death certificate is accuracy of death causes with who standards and death causes codes in icd10....

OBJECTIVE To evaluate trends in feedlot cattle mortality ratios over time, by primary body system affected, and by type of animal. DESIGN Retrospective cohort study. ANIMALS Approximately 21.8 million cattle entering 121 feedlots in the United States during 1994 through 1999. PROCEDURES Yearly and monthly mortality ratios were calculated. Numbers of deaths were modeled by use of Poisson r...