conclusions mp, flub and rsv are the principal contributors to ari in the hubei area, with mixed infections, typically of mp and flub, being the most common pathogens statistically significant between different age groups. background acute respiratory infection (ari) is one of the primary diseases that cause high morbidity and mortality to children especially in developing countries. ari can co...

A wide range of viruses affect the respiratory tract of transplant recipients, including adenovirus, influenza, human metapneumovirus, parainfluenza virus, respiratory syncytial virus (RSV) and rhinovirus. Prospective studies using contemporary diagnostic techniques have recently improved our understanding of the epidemiology and importance of these respiratory viruses among transplant recipien...

Mutant recombinant respiratory syncytial viruses (RSV) which cannot express the NS1 and M2-2 proteins, designated rA2DeltaNS1 and rA2DeltaM2-2, respectively, were evaluated as live-attenuated RSV vaccines. The rA2DeltaNS1 virus contains a large deletion that should have the advantageous property of genetic stability during replication in vitro and in vivo. In vitro, rA2DeltaNS1 replicated appro...

Severe fulminant myocarditis causing cardiogenic shock can be a rapidly progressing, life threatening condition. Respiratory syncytial virus (RSV) is a very rare infectious culprit infrequently described in medical literature as a cause of myocarditis, particularly in adults. We present a case of acute fulminant myocarditis in a patient with PCR positive RSV infection requiring venoarterial ext...

BACKGROUND Respiratory syncytial virus (RSV) is a leading etiological agent of acute respiratory tract infections and hospitalizations in children. However, little information is available regarding RSV infections in Latin American countries, particularly among adult patients. OBJECTIVE To describe the epidemiology of RSV infection and to analyze the factors associated with severe infections ...

We present a case of acute respiratory failure developing in a patient given immunosuppression for anti-neutrophil cytoplasm antibody (ANCA)-positive renal vasculitis. With these interventions, however, comes the increased risk of infective complications. This case highlights a highly unusual (but probably underdiagnosed) infection, respiratory syncytial virus (RSV), associated with severe pneu...

Respiratory syncytial virus (RSV) is known to cause annual epidemics of respiratory infections; however, the lack specific treatment options for this disease poses a challenge. In light this, there has been concerted effort identify small molecules that can effectively combat RSV. This article focuses on mechanism action compound K142, which was identified as primary screening leader in earlier...

The contribution of human metapneumovirus (hMPV) relative to that of other respiratory viruses as a cause of respiratory infections in children less than 1 year old has been evaluated. From October 2003 to April 2004, nasopharyngeal samples from 211 children less than 1 year old were analyzed to detect respiratory viruses. Respiratory syncytial virus (RSV) was the predominant virus isolated (96...

An upper respiratory tract infection in a 22-month-old boy was followed by rapid loss of consciousness, hypoglycaemia, uraemia, and death. Necropsy examination showed fatty change of liver and kidneys, severe cerebral oedema, bronchiolitis, and endocardial fibroelastosis affecting the left ventricle. Immunofluorescence staining showed infection with respiratory syncytial virus (RSV). The clinic...

Respiratory insufficiency due to respiratory syncytial virus (RSV) bronchiolitis is partly due to the abundance of thickened mucus and the inability to clear it from the airways. Mucus in RSV bronchiolitis contains necrotic inflammatory and epithelial cells. The viscoelastic properties of purulent airway secretions are largely due to the presence of highly polymerized deoxyribonucleic acid (DNA...