Biermer’s disease also called: Addison’s anemia or in old textbooks, pernicious anemia, is an autoimmune disease, caused by impaired absorption of cobalamin (vitamin B12) owing to the neutralization of intrinsic factor action in the setting of immune atrophic gastritis [1]. In adults and elderly patients, this form of megaloblastic anemia is one of the leading causes of cobalamin deficiency, wi...

The association of megaloblastic vitamin B12 deficiency anemia and essential thrombocythemia is very rarely described in the literature. We reported a case 65-year-old patient with an isolated chronic anemic syndrome secondary to treated therapy by injection. evolution was marked three months after treatment ischemic cerebrovascular accident thrombocytosis. Additional investigations confirmed thr...

ECENTLY we have had the opportunity to study a patient with a macrocytic anemia and megaloblastic bone marrow, who was refractory to parenteral therapy with vitamin B,2 and refined liver extract, but who responded to folic acid. This type of macrocytic anemia is rare, particularly in this country. Observations made in this case support the concept of a chemical interrelationship between liver e...

A patient with severe arsenic poisoning that resulted in marked peripheral blood and bone marrow abnormalities, including megaloblastic erythropoiesis experienced many of the previously reported hematologic complications of arsenic poisoning: leukopenia, granulocytopenia, absolute eosinophilia, and profound anemia. In this study we report an ultrastructural and electron-probe analysis of the bo...

Repeated bone marrow examination was found to be of value in assessing response to treatment in megaloblastic anemia. The objective of this study was monitoring the response of megaloblastics to treatment, concerning the location of neutrophilic myeloperoxidase and myeloperoxidase index (MPXI) and their variation in megaloblastic erythroid progeny. It is possible to follow up megaloblastic ...

Recent studies using anion exclusion chromatography have suggested that uracil is misincorporated into the DNA of patients with megaloblastic anemia to levels detectable by nonradioactive methods. We have investigated the nucleotide composition of DNA from the bone marrow mononuclear cells of eight patients with cobalamin deficiency and compared this with that found in normal subjects. The medi...