The primary trigger to periodic limb movement (PLM) during sleep is still unknown. Its association with the restless legs syndrome (RLS) is established in humans and was reported in spinal cord injury (SCI) patients classified by the American Spinal Injury Association (ASIA) as A. Its pathogenesis has not been completely unraveled, though recent advances might enhance our knowledge about those ...

CONTEXT Restless legs syndrome (RLS) is an irresistible urge to move legs that usually occur during inactivity and at night. This neurologic condition is associated with increased risk of nocturnal hypertension as well as cardiovascular events and affects patient's sleep, which leads to anxiety, depression, and decreases quality of life. Presence of RLS in patients on hemodialysis is associated...

Introduction: Restless legs syndrome (RLS) is a neurological disorder with a prevalence of about 5-10% of the general population. Its clinical symptom is characterized by uncontrollable, unbearable urges to move the legs, causing chronic sleep deprivation. The iron deficiency has been considered an important contributing factor for RLS [1]. In vivo iron evaluation for RLS has largely utilized T...

INTRODUCTION: The association of Sleep-Related Movement Disorders (SRMDs) such as Restless Legs Syndrome (RLS) and Periodic Limb Movements (PLMs) with cerebrovascular disease is underexplored. Emerging evidence links them to vascular disease, for which white matter hyperintensities (WMHs) are a well-recognized

Restless legs syndrome (RLS) is a disease characterized by the presence of an urge to move the legs accompanied by unpleasant sensations in the legs. The symptoms appear or increase in the evening and during the night, they are provoked by rest, and are totally or partially relieved by moving the legs [1, 2] . Diagnosis of RLS is based solely on the presence of the abovementioned symptoms witho...

Restless legs syndrome (RLS) is a sensorimotor disorder that often has a profound impact on sleep 1) . The etiology is unknown, but is related to iron deficiency anemia (IDA) and family history. There are four essential criteria for diagnosis of RLS in adults 1) . First, there should be an urge or unpleasant sensation to move the legs; second, those urges begin or worsen during periods of rest ...

Restless legs syndrome/Willis-Ekbom disease (RLS/WED) is a chronic neurosensory disorder that is characterized by a strong urge to move, accompanied by an uncomfortable paresthesia in the legs which affects about 5-15 percent of adult people in industrialized countries.1 RLS/WED is a puzzling disease, mostly because of the uncertainty of its etiology. There seems to be a genetic component, but ...

PATIENTS AND METHODS To assess the reliability, validity, and responsiveness of the International Restless Legs Syndrome Study Group's rating scale (the International Restless Legs Scale (IRLS)) (V2.0), using pooled data from two matching, placebo-controlled studies of ropinirole for treating Restless Legs Syndrome (RLS). RESULTS Pooled patient samples comprised 550 patients in the baseline (...

background and objective : restless legs syndrome (rls) is a sleep disorder with an association to sleep quality. we investigated the sleep quality in patients with rls among health-care workers with or without shift work. materials and methods : all female health-care workers (n = 540) in four educational hospitals were enrolled in this cross-sectional study. international rls study group (irl...

OBJECTIVE Restless legs syndrome (RLS), also known as Willis-Ekbom disease, is a sensorimotor disorder that can result in considerable sleep disruption. This narrative review provides an overview of RLS diagnosis and reports epidemiologic evidence for an association between RLS and mood disorders. Possible links between RLS, sleep disturbances, and mood disorders are considered, and theoretical...