Several signaling pathways and transcription factors control the cell fate in its in vitro development and differentiation. The orchestrated use of these factors results in cell specification. In coculture methods, many of these factors secrete from host cells but control the process. Today, transcription factors required for retinal progenitor cells are well known, but the generation of these ...

Retinal neovascularization is the most common cause of blindness; Retinopathy of pre-maturity (ROP) for children and diabetic retinopathy for young age group. ROP still remains as the most serious cause of vision loss in children. We provided that deguelin significantly reduces retinal neovascularization in a mouse model of ROP. Deguelin never affected the transcriptional activity of hypoxia in...

Background: Retinal toxicity from hydroxychloroquine (HCQ) is rare, but the vision loss maybe irreversible and could have medicolegal consequences. Objectives: To determine prevalence assess predictors of retinal due to HCQ in patients with rheumatic diseases. There paucity literature on Methods: A retrospective observational study was conducted Department Clinical Immnuology Rheumatology, Sri ...

Purpose: To present a case of chemotherapy regimen combining fibroblast growth factor receptor (FGFR) and mitogen-activated protein kinase (MEK) inhibitor leading to serous retinopathy. Methods: A retrospective chart review single was performed. Results: 67-year-old man with pancreatic prostate cancer developed bilateral multifocal pockets subretinal fluid while on an experimental MEK (trametin...

Spinocerebellar ataxia type 7 (SCA7) is an autosomal dominant neurodegenerative disease characterized by loss of motor coordination and retinal degeneration with no current therapies in the clinic. The causative mutation is an expanded CAG repeat in the ataxin-7 gene whose mutant protein product causes cerebellar and brainstem degeneration and retinal cone-rod dystrophy. Here, we reduced the ex...