Vasculitis is not an uncommon diagnosis, however ocular manifestations of vasculitis may at times be presenting symptoms of the disease, requiring an earnest effort on part of the ophthalmologist. In the eye, retinal vessels are the most susceptible to inflammation and sometimes, ocular signs may provide vital clues to the systemic etiology. This review of ocular manifestations of vasculitis is...

Idiopathic retinal vasculitis, aneurysm, and neuroretinitis (IRVAN) syndrome, pigmented paravenous chorioretinal atrophy (PPCRA) are rare clinical manifestations of unknown etiology. In recent years, with the widespread use multimodal imaging methods in diseases, information about pathogenesis course these diseases has increased. PPCRA is often detected incidentally asymptomatic, whereas IRVAN,...

PURPOSE To evaluate the usefulness of the interferon-gamma release assay (IGRA) for diagnosing tuberculosis (TB)-related uveitis (TRU). METHODS Records from 181 patients with ocular signs and symptoms suggestive of TRU and intraocular inflammation of unknown etiology were reviewed. All subjects underwent clinical and laboratory testing, including IGRA, to rule out presence of underlying disea...

PURPOSE To report a case of central retinal artery occlusion (CRAO) in a patient with biopsy-verified Wegener's granulomatosis (WG) with positive C-ANCA. METHODS A 55-year-old woman presented with a 3-day history of acute painless bilateral loss of vision; she also complained of fever and weight loss. Examination showed a CRAO in the left eye and angiographically documented choroidal ischemia...

PURPOSE To investigate whether polymorphisms in the gene encoding the chemokine receptor CX3CR1, which has been linked to changes in functional ligand-binding activity, are associated with retinal vasculitis (RV) in a cohort of patients in the United Kingdom. METHODS DNA was prepared from whole blood of 126 patients with RV and 95 healthy individuals by a standard salting-out procedure. Two p...

The retinal arteries and veins may be involved in isolation or as the result of a systemic vasculitis. This article emphasizes neurologic diseases in which the ocular vasculature is affected.