The transition from nucleate to film boiling on micro/nanotextured surfaces is of crucial importance in a number practical applications, where it needs be avoided enable safe and efficient heat transfer. Previous studies have focused the process at macroscale, transfer bubble generation are activated an array micro/nanostructures. In present study, we narrow down our investigation scale single ...

The optical light-curves of GRB afterglows 990123 and 021211 exhibit a steep decay at 100–600 seconds after the burst, the decay becoming slower after about 10 minutes. We investigate two scenarios for the fast decaying early optical emission of these GRB afterglows. In the reverse-forward shock scenario, this emission arises in the reverse shock crossing the GRB ejecta, the mitigation of the l...

Sepsis is thought to result from an exaggerated innate immune response to microbial components such as lipopolysaccharide (LPS), but the involvement of a specific mechanism(s) has not been identified. We studied the role of caspase 1 (Cas-1) in the murine innate immune response to infection with gram-negative bacteria and to nonlethal and lethal doses of LPS. cas-1(-/-) and Cas-1 inhibitor (Ac-...

Adenosine induces vasoconstriction of renal afferent arterioles through activation of A1 adenosine receptors (A1AR). A1AR are directly coupled to Gi/Go, resulting in inhibition of adenylate cyclase, but the contribution of this signaling pathway to smooth muscle cell activation is unclear. In perfused afferent arterioles from mouse kidney, adenosine and the A1 agonist N(6)-cyclohexyladenosine, ...

We present a fluorimetry-based technology for micro-RNA-21 (miR-21) sensing based on the concentration of miR-molecular beacon (MB) complexes and flushing unbound MB. This module consists microfluidic channel with shape funnel operated electrohydrodynamic actuation. report limit detection 2 pM in less than 1 min miR-21 alone, then demonstrate that levels, measured fine needle biopsy samples, fr...

RNA quality control is a crucial step in guaranteeing integer nondegraded RNA and receiving meaningful results in gene expression profiling experiments, using micro-array, RT-qPCR (Reverse-Transcription quantitative PCR), or Next-Generation-Sequencing by RNA-Seq or small-RNA Seq. Therefore, assessment of RNA integrity and purity is very essential prior to gene expression analysis of sample RNA ...

A multi-product model for the design of global supply chains with reverse flows is proposed. Two levels of decisions are considered, one strategic and one tactical. The first is modelled through a macro perspective of time where the determination of the network structure and flows is accomplished. At tactical level, a micro perspective of time is considered, where production planning and invent...

This paper presents the advances done in the field of simulation and design applied to MEMS. It will be discussed some techniques to link different finite element softwares, especially COMSOL and ANSYS, in order to profit from all the advantages offered by each finite element code. Then, an explication is done on how we piloted ABAQUS using a Matlab routine. In a third and very important sectio...

We present in this paper the findings of a study on the role of macroadaptation in conversational intelligent tutoring. Macro-adaptivity refers to a system’s capability to select appropriate instructional tasks for the learner to work on. Micro-adaptivity refers to a system’s capability to adapt its scaffolding while the learner is working on a particular task. We compared an intelligent tutori...