OBJECTIVES We sought to assess the prevalence and progression of neo-aortic root dilation and valvar regurgitation after staged reconstruction for hypoplastic left heart syndrome (HLHS). BACKGROUND In HLHS, the pulmonary valve functions as the neo-aortic valve. Neo-aortic valve dysfunction has been observed after arterial switch operation and the Ross procedure. METHODS Patients with HLHS b...

Cell cycle checkpoints are evolutionarily conserved signaling pathways that uphold genomic integrity. Complete inactivation of the mouse checkpoint gene Hus1 results in chromosomal instability, genotoxin hypersensitivity, and embryonic lethality. To determine the functional consequences of partial Hus1 impairment, we generated an allelic series in which Hus1 expression was incrementally reduced...

INTRODUCTION Human personality is described preferentially in terms of factors (dimensions) found using factor analysis. An alternative and highly related method is network analysis, which may have several advantages over factor analytic methods. AIM To directly compare the ability of network community detection (NCD) and principal component factor analysis (PCA) to examine modularity in mult...

OBJECTIVE After the arterial switch operation (ASO), disproportional neo-aortic growth during childhood has been reported. Even though it has been suggested neo-aortic dilation will stabilise in adulthood, data are lacking. The aim of this study was to assess the change in neo-aortic dimensions, prevalence of neo-aortic dilation >40 mm and long-term outcome in adults who underwent ASO in childh...

Personality traits have been suggested as potential endophenotypes for Bipolar Disorder (BP), as they can be quantitatively measured and show correlations with BP. The present study utilized data from 2,745 individuals from 686 extended pedigrees originally ascertained for having multiplex cases of BP (963 cases of BPI or schizoaffective BP). Subjects were assessed with the NEO Personality Inve...

This prospective study examined the extent to which the personality traits neuroticism, extraversion and agreeableness and coping styles approach, avoidant and ambivalent contribute to the development of depressive symptoms in adult burns survivors at three months post-injury. Participants were 70 adult burns survivors admitted to Royal Perth Hospital in Western Australia between June 2007 and ...

Although intended to assess vulnerability factors associated with psychopathology, the 5-Dimensional Personality Test (5DPT) shows at least a superficial similarity to instruments that adhere to the lexical tradition in personality psychology. To investigate to which extent this similarity goes, this article compares the 5DPT with 2 lexically based measures, the NEO-Five Factor Inventory and th...

Psychopathy is a personality disorder that includes interpersonal-affective and antisocial deviance features. The Psychopathic Personality Inventory (PPI) contains two underlying factors (fearless dominance and impulsive antisociality) that may differentially tap these two sets of features. In a mixed-gender sample of undergraduates and prisoners, we found that PPI fearless dominance was relate...

BACKGROUND Consequences of war-related traumatisation have mostly been investigated in military and predominant male populations, while research on female civilian victims of war has been neglected. Furthermore, research of post-war posttraumatic stress disorder (PTSD) in women has rarely included early-life trauma in their prediction models, so the contribution of trauma in childhood and early...