نتایج جستجو برای: rfc1

تعداد نتایج: 133  

Journal: :Sleep 2023

Abstract Introduction Cerebellar ataxia with neuropathy and vestibular areflexia syndrome (CANVAS) is a rare disorder caused by an autosomal recessive biallelic pentanucleotide repeat expansion in the replication factor C subunit 1 (RFC1) gene. Clinical features include gait disturbances, impaired vibratory sensation, autonomic dysfunction, cough, slow disease progression. Spinocerebellar ataxi...

2017
Benjamin O Wade Hon Wing Liu Catarina P Samora Frank Uhlmann Martin R Singleton

Replication factor C complexes load and unload processivity clamps from DNA and are involved in multiple DNA replication and repair pathways. The RFC variant complex is required for activation of the intra-S-phase checkpoint at stalled replication forks and aids the establishment of sister chromatid cohesion. Unlike other RFC complexes, RFC contains two non-Rfc subunits, Dcc1 and Ctf8. Here, we...

Journal: :The EMBO journal 1997
E Rhéaume L Y Cohen F Uhlmann C Lazure A Alam J Hurwitz R P Sékaly F Denis

Caspase-3 is an ICE-like protease activated during apoptosis induced by different stimuli. Poly(ADP-ribose) polymerase (PARP), the first characterized substrate of caspase-3, shares a region of homology with the large subunit of Replication Factor C (RF-C), a five-subunit complex that is part of the processive eukaryotic DNA polymerase holoenzymes. Caspase-3 cleaves PARP at a DEVD-G motif prese...

Journal: :The Journal of biological chemistry 2006
Aaron Johnson Nina Y Yao Gregory D Bowman John Kuriyan Mike O'Donnell

Replication factor C (RFC) is an AAA+ heteropentamer that couples the energy of ATP binding and hydrolysis to the loading of the DNA polymerase processivity clamp, proliferating cell nuclear antigen (PCNA), onto DNA. RFC consists of five subunits in a spiral arrangement (RFC-A, -B, -C, -D, and -E, corresponding to subunits RFC1, RFC4, RFC3, RFC2, and RFC5, respectively). The RFC subunits are AA...

Journal: :International journal of molecular medicine 2015
Zhicheng Yao Kunpeng Hu He Huang Shilei Xu Qingliang Wang Peng Zhang Peisheng Yang Bo Liu

Hepatocellular carcinoma (HCC) is one of the most common and lethal malignancies worldwide. Replication factor C (RFC) plays an important role in DNA replication and checkpoint control during the cell cycle. RFC is comprised of one large subunit [replication factor C, subunit 1 (RFC1)] and four small subunits [replication factor C, subunits 2-5 (RFC2‑5)]. The role of RFC3 in the development of ...

Journal: :Molecular and cellular biology 1998
V N Noskov H Araki A Sugino

Replication factor C (RF-C), an auxiliary factor for DNA polymerases delta and epsilon, is a multiprotein complex consisting of five different polypeptides. It recognizes a primer on a template DNA, binds to a primer terminus, and helps load proliferating cell nuclear antigen onto the DNA template. The RFC2 gene encodes the third-largest subunit of the RF-C complex. To elucidate the role of thi...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009
Simon M Collin Chris Metcalfe Luisa Zuccolo Sarah J Lewis Lina Chen Angela Cox Michael Davis J Athene Lane Jenny Donovan George Davey Smith David E Neal Freddie C Hamdy Julius Gudmundsson Patrick Sulem Thorunn Rafnar Kristrun R Benediktsdottir Rosalind A Eeles Michelle Guy Zsofia Kote-Jarai Jonathan Morrison Ali Amin Al Olama Kari Stefansson Douglas F Easton Richard M Martin

Folate-pathway gene polymorphisms have been implicated in several cancers and investigated inconclusively in relation to prostate cancer. We conducted a systematic review, which identified nine case-control studies (eight included, one excluded). We also included data from four genome-wide association studies and from a case-control study nested within the UK population-based Prostate Testing f...

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