Dr. K. Okada, Second Department of Internal Medicine, Nihon University School of Medicine, Tokyo 173 (Japan) Dear Sir, A corrective effect for recombinant human erythropoietin (rhEPO) in the treatment of anemia in hemodialyzed patients has been reported [1, 2]. The Ad Hoc Committee for the National Kidney Foundation has indicated that rhEPO should be administered intravenously three times a wee...

Kiyoshi Morikawa, Department of Clinical and Laboratory Science, Fukui Medical School, Matsuoka, Yoshida-gun, Fukui 910-11 (Japan) phore, ionomycin (Wako Pure Pharmaceutical, Tokyo, Japan), with a chemotactic pep-tide, FMLP (Peptide Institute, Osaka, Japan), or with epoetin-α (EPO, Kirin Beer Co. Ltd., Tokyo, Japan). In a short coculture study, at a concentration of 10,000 mlU/ml of rhEPO, morp...

The reliable determination of human recombinant erythropoietin (rhEpo) abuse to enhance the athletic performance is an important problem for sport and represents a continuous challenge for investigators involved in anti-doping. The analytical tests used to detect rhEpo in urines are often inadequate and suffer from many interfering factors. Hepcidin, a liver-derived peptide which is the major r...

Hemodialysis patients treated with recombinant human erythropoietin (rhEPO) need adequate iron supplementation to avoid rhEPO hyporesponsiveness due to iron deficiency. Low serum ferritin reflects absolute iron deficiency, whereas normal or high ferritin values in combination with low transferrin saturation (< 20%) indicate functional iron deficiency. In this study, healthy subjects (group I) w...

Abstract Background and Aims Daprodustat (GSK1278863) is a hypoxia-inducible factor prolyl hydroxylase inhibitor under investigation for the treatment of anaemia chronic kidney disease. Phase 3 studies in dialysis (ASCEND-D) non-dialysis (ASCEND-ND) patients demonstrated non-inferiority daprodustat vs recombinant human erythropoietin (rhEPO) control (in ASCEND-D) or darbepoetin alfa terms mean ...

conclusions our case report showed the therapeutic effect of rhepo in complete curing of povl. regarding the side effects of epo such as thrombogenic effects or mild hemodynamic changes like transient sinus tachycardia during infusion, it seems that beneficial effects of epo is more than its disadvantages and expenses, for patients with povl. case presentation our patient was a 61-year-old man,...

have been reported by several authors [2,3,6 ]. The Introduction high total serum concentration of carnitine results predominantly from an increase in -carnitine esters, Recombinant human erythropoietin (rhEpo) is widely i.e. acylcarnitine. As a result of the reduction in free used for correction of anaemia in patients with endcarnitine, the ratios of free/total carnitine and free stage renal ...

UNLABELLED Selective neuronal loss following status epilepticus (SE) was first described just under 100 years ago. The acute pathology following SE was shown to be 'ischemic cell change' and was assumed to arise through hypoxia/ischemia. Recently, erythropoietin (Epo) has been shown to have potent anti-apoptosis activity in central nervous system neurons in animal models of ischaemic injury. ...

BACKGROUND AND OBJECTIVE The effectiveness of recombinant human erythropoietin (rhEpo) in accelerating erythroid engraftment in patients undergoing allogeneic bone marrow transplantation (BMT) has been demonstrated in previous studies. On the other hand, there are experimental data suggesting that high doses of rhEpo might also exert a stimulatory effect on thrombopoiesis. METHODS We carried ...