Penicillamine has been used in the treatment of patients with rheumatoid arthritis with variable clinical response (Jaffe, 1963; Camus, Guillien, Crouzet, Schaeffer, and Lievre, 1970; Zuckner, Ramsey, Dorner, and Gantner, 1970; Golding, Wilson, and Day, 1970). Moreover, observations on the effect of this drug on serum immunoglobulins and rheumatoid factor titres have yielded conflicting and ind...

The prolonged administration of the sulphydryl compound penicillamine to rheumatoid arthritis patients results in a fall in the titre of rheumatoid factor (Jaffe, 1963). The mechanism by which the drug produces this effect is unknown, though it does not appear to be by intravascular depolymerization of macroglobulins (Jaffe, 1964) or by immunosuppression by pyridoxine antagonism (Jaffe, 1965). ...

Serum samples from patients with seropositive rheumatoid arthritis contain an inhibitor of complement mediated inhibition of immune precipitation (CMIP). This inhibitory effect can be produced by the addition of either purified monoclonal or polyclonal IgM rheumatoid factor (RF) to human serum. The specificity of the rheumatoid factor influences the degree of inhibition, and when precipitation ...

The need for the isolation of rheumatoid factor in a high state of purity and in sufficient quantity for antiserum production has led to an appraisal of the various purification methods available. Ziff, Brown, Lospalluto, Badin, and McEwen (1956) demonstrated that the sensitized sheep cell agglutinating activity of rheumatoid serum was precipitated in the euglobulin fraction, and Svartz and Sch...

Yes. Testing for anti-cyclic citrullinated peptide (anti-CCP) antibody can help diagnose rheumatoid arthritis (RA) because it is a highly specific test. For many years, the diagnosis of RA has been based on the presentation of symmetrical smalland large-joint polyarthritis that spares the lower spine, further supported by the presence of characteristic joint damage on radiography and an elevate...

The performance of two immunoturbidimetric modifications for rheumatoid factor (RF) testing, which differ with respect to the means of complement inactivation (heat treatment and inactivation with polyvinyl sulphonate), were compared in serum samples from 87 patients with rheumatoid arthritis (RA) and from 403 healthy subjects. IgM-rheumatoid factor titres were also measured with an enzyme link...

Four assays of rheumatoid factor (RF) have been measured on serum from 213 individuals from 13 families containing at least two sufferers from classical or definite rheumatoid arthritis (RA). Families were not uniformly RF positive or negative, and there was no evidence that non-RA RF positivity was inherited. Four individuals developed definite RA over a two year period, showing that the famil...

BACKGROUND Fluorescence-enhancing microarray on plasmonic gold film is an attractive alternative to traditional enzyme-linked immunosorbent assay (ELISA) for cytokine detection because of the increased sensitivity. The assay chemistry is similar to an ELISA sandwich assay, but owing to the gold substrate, cytokine measurements are 10 to 100 times more sensitive and can be multiplexed. Plasmonic...