نتایج جستجو برای: rhodanine assay

تعداد نتایج: 221895  

Journal: :Physical chemistry chemical physics : PCCP 2010
Maria Hahlin Erik M J Johansson Stefan Plogmaker Michael Odelius Daniel P Hagberg Licheng Sun Hans Siegbahn Håkan Rensmo

The electronic and molecular properties of three organic dye molecules with the general structure donor-linker-anchor have been investigated using core level photoelectron spectroscopy (PES). The molecules contain a diphenylaniline donor unit, a thiophene linker unit, and cyanoacrylic acid or rhodanine-3-acetic acid anchor units. They have been investigated both in the form of a multilayer and ...

Journal: :Journal of medicinal chemistry 2007
Lawrence M Szewczuk S Adrian Saldanha Surajit Ganguly Erin M Bowers Margarita Javoroncov Balasubramanyam Karanam Jeffrey C Culhane Marc A Holbert David C Klein Ruben Abagyan Philip A Cole

Serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AANAT) is a member of the GCN5 N-acetyltransferase (GNAT) superfamily and catalyzes the penultimate step in the biosynthesis of melatonin; a large daily rhythm in AANAT activity drives the daily rhythm in circulating melatonin. We have used a structure-based computational approach to identify the first druglike and selective inh...

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