نتایج جستجو برای: ribonucleoprotein
تعداد نتایج: 6284 فیلتر نتایج به سال:
We have investigated the feasibility of using human autoimmune antibodies to isolate and characterize specific nuclear ribonucleoprotein (nRNP) complexes. High titers of anti-nRNP antibodies occur in a syndrome called mixed connective tissue disease. IgG antibodies from two mixed connective tissue disease patients were used to construct affinity columns to isolate the antigenic complexes from r...
Introduction Conclusions References
As mRNAs are generated, they are clothed with proteins to form messenger ribonucleoprotein particles (mRNPs), which are then actively remodeled during various steps of gene expression. Franks et al. (2010) now show that mRNP remodeling is required even for the death of an mRNA.
In the current model for spliceosome assembly, U1 snRNP binds to the 5' splice site in the E complex followed by ATP-dependent binding of U2 snRNP to the branchpoint sequence (BPS) in the A complex. Here we report the characterization of highly purified, functional E complex. We provide evidence that this complex contains functional U2 snRNP and that this snRNP is required for E complex assembl...
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