Chromosome ring formation has been found in a number of difierent genera. In certain species of Oenothera and of Hypericum and in the monotypic genus Rhoeo, all the chromosomes may be united in a single ring or chain a t meiosis. Ring formation is maintained in these plants by a system of balanced lethals. In Datura, Zea, Pisum and Campanula rings of four or more chromosomes have been described...

UNLABELLED Ring chromosome aberration are rare abnormality potentially involving any chromosome in patients diagnosing in Oncology. The present review and case study has focused on the ring chromosome associated with oncology malignancies. MATERIAL AND METHODS An electronic peer review article search was performed systematically to obtain relevant literature with the CINAHL, Google scholar, a...

The ring chromosome is a circular, structural abnormality composed of either multiple chromosomes or a single chromosome with loss of genetic material at one or both ends. This chromosomal rearrangement is often unstable with frequent recombinations and may be accompanied by either loss or amplification of genetic material[1]. Considering that ring chromosomes are rare in acute myelogenous leuk...

Ring chromosomes in man have been described not only as interesting phenomena associated with irradiation and neoplasia (Levan, 1956; Tough et al., 1960; Bender and Gooch, 1962; Jensen, 1966) but also as a probable cause of congenital malformations (Palmer, Fareed, and Merritt, 1967). In the cases of congenital malformations so far ascribed to ring chromosomes, the B group has been involved onl...

A female child born preterm with intrauterine growth retardation and presenting with facial dysmorphism with clefts, microcephaly, limb deformities, and congenital abnormalities involving cardiovascular and urinary systems is described. Chromosomal analysis showed a de novo 46,XX,r(4)(p15.3q35) karyotype. The clinical features of the patient were compared with the phenotypic characteristics of ...

Endogenious opiod met-enkephalin throughout previous research manifested cytoprotective and anti-inflammatory effects. Previous research suggests that met-enkephalin has cytogenetic effects. Reducement in the frequency of structural chromosome aberrations as well as a suppressive effect on lymphocyte cell cycle is found. It also reduces apoptosis in the blood samples of the patients with immune...

After the first report of a ring chromosome in a case of human leukemia by Sandberg et al., ring chromosomes have been infrequently (!10%) detected in hematopoietic neoplasias [1,2]. In most cases, however, ring chromosomes were part of a more or less complex karyotype associated with a poor prognosis [2]. As far as we know, there was no detailed, confirmatory report on an association between a...

Human telomeres play a major role in stabilizing chromosome ends and preventing fusions. Chromosomes bearing a broken end are rescued by the acquisition of a new telomeric cap without any subtelomeric sequences being present at the breakpoint, a process referred to as chromosome healing. Conversely, a loss of telomeric function or integrity can lead to the presence of interstitial telomeres at ...

We report a case of a neonate who was shown with routine chromosome analysis on peripheral blood lymphocytes to have full monosomy 21. Further investigation on fibroblast cells using conventional chromosome and FISH analysis revealed two additional mosaic cell lines; one is containing a ring chromosome 21 and the other a double ring chromosome 21. In addition, chromosome microarray analysis (CM...