This dissertation is based on the following original publications on non-irradiated, irradiated, and metastatic uveal melanoma. The original publications in the text will be referred to by their Roman numerals I-IV: in regressed and partially regressed irradiated choroidal and ciliary body melanomas.infiltrating macrophages in choroidal and ciliary body melanoma and corresponding metastases. II...

Environmental risk factors for uveal melanomas (cancer of the iris, ciliary body, and choroid) have not been identified. To search for these, we examined the correlation of age-adjusted eye cancer incidence rates, a surrogate for uveal melanoma rates, in U.S. states with group level geographic and demographic factors using multivariate linear regression. Incidence rates for eye cancer were inve...

introduction primary malignant esophageal melanoma makes up 0.1% to 0.2% of all esophageal malignancies. most physicians assume malignant melanoma as a skin originated neoplasm, however this type of melanoma can occur anywhere in the gastrointestinal tract especially in the esophagus. thus, it is essential to consider malignant melanoma in differential diagnosis of any esophagus masses. case pr...

PurposeNormal tissue complication probability (NTCP) models could aid the understanding of dose dependence radiation-induced toxicities after eye-preserving radiotherapy choroidal melanomas. We performed NTCP-modeling and established dose-response relationships for visual acuity (VA) deterioration common late complications treatments with proton therapy (PT).DesignRetrospective study from singl...

BACKGROUND Uveal melanoma is the most common primary intraocular tumor in adults. In the last two decades the Hadassah-Hebrew University Medical Center ocular oncology clinic has become a referral center for uveal melanoma patients. OBJECTIVES To describe the characteristics of uveal melanoma patients in Israel, their treatment modalities and outcomes during the years 1988-2007. METHODS Dat...

malignant melanoma has the heart metastasis rate of 50 - 71%, which seems to be the highest among other malignancies. when a patient presents with cardiac metastases of melanoma, the disease has already spread through the body and therefore hardly curable. this brief review tried to introduce this important condition and discuss its frequency, presentation, diagnosis, histologic findings and tr...

PURPOSE To determine independent predictors of exudative retinal detachment (RD) in eyes with uveal melanoma and the significance of RD in melanoma-specific survival. METHODS The extent of exudative RD was recorded retrospectively in a population-based cohort of 167 consecutive patients with eyes enucleated from 1972 through 1981 because of choroidal and ciliary body melanoma, representing al...

PURPOSE The case reports presented here were compiled to demonstrate the potential for improved diagnosis and monitoring of disease progress of intraocular lesions using ultrahigh-field magnetic resonance microscopy (MRM) at 7.1 Tesla. METHODS High-resolution ex vivo ocular magnetic resonance (MR) images were acquired on an ultrahigh-field MR system (7.1 Tesla, ClinScan, Bruker BioScan, Germa...