Retinal rod photoreceptors of teleost fish elongate in the light and shorten in the dark. Rod cell elongation and shortening are both mediated by actin-dependent mechanisms that occur in the inner segment myoid and ellipsoid. The intracellular signaling pathways by which light and dark regulate the actin cytoskeleton in the inner segment are unknown. To investigate the intracellular signals tha...

INTRODUCTION Disabilities due to stroke lead to a serious individual and socioeconomic burden. In this presented hospital-based study, we aimed to evaluate recurrent ischemic stroke (RIS) characteristics and the sufficiency of secondary prevention regarding the most common modifiable risk factors. METHODS The records of patients with a diagnosis of ischemic stroke between November 2009 and No...

The technology for acquiring, storing, retrieving, displaying, and distributing images has advanced dramatically in recent years. The push is toward enterprise-wide image management solutions, where digital images from radiology, cardiology, and other "ologies" are seamlessly linked with information from clinical information systems and other databases, and they are accessed seamlessly from a s...

A moving target tracking algorithm is proposed here and implemented on the Anafocus Eye-RIS vision system, which is a compact and modular platform to develop real time image processing applications. The algorithm combines moving-object detection with feature extraction in order to identify the specific target in the environment. The algorithm was tested in a mobile robotics experiment in which ...

A computer system that improves the quality, user-friendliness, accessibility, and management of radiology data (images, reports, databases, knowledge) was implemented at a private institute. A picture archiving and communication system (PACS) was integrated with the radiology information system (RIS). Two servers and 12 personal computers form the integrated system. The first server is dedicat...

Storing and retrieving radiology cases is an important activity for education and clinical research, but this process can be time-consuming. In the process of structuring reports and images into organized teaching files, incidental pathologic conditions not pertinent to the primary teaching point can be omitted, as when a user saves images of an aortic dissection case but disregards the inciden...

Farnesyl pyrophosphate synthase (FPPS) is the major molecular target of nitrogen-containing bisphosphonates (N-BPs), used clinically as bone resorption inhibitors. We investigated the role of threonine 201 (Thr201) and tyrosine 204 (Tyr204) residues in substrate binding, catalysis and inhibition by N-BPs, employing kinetic and crystallographic studies of mutated FPPS proteins. Mutants of Thr201...

background: the aim of this study was to estimate the conversion rate from radiologically isolated syndrome (ris) to definite multiple sclerosis (ms). methods: during a mean (standard deviation [sd]) follow-up period of 17.4 (5.4) (range 8-29) months, 25 subjects with ris and without neurological symptom aged 22-45 year from a single-center have been examined for the occurrence of definite ms. ...

Despite the definition of specific diagnostic criteria to identify radiologically isolated syndrome (RIS) suggestive of multiple sclerosis, its natural history remains incompletely understood. We retrospectively analyzed a Brazilian cohort of 12 patients to clarify their features and to emphasize the role of imaging predictors in clinical conversion. We demonstrated that, although some individu...

To prevent information leakage in multilevel secure data models, the concept of polyinstantiation was inevitably introduced. Unfortunately, when it comes to references through foreign key in multilevel relational data models, the polyinstantiation causes referential ambiguities. To resolve this problem, this paper proposes an extended referential integrity semantics for a multilevel relational ...