in vitro lymphocyte responses of high responder (hr) and low responder (lr) guinea pigs from pe-ripheral blood lymphocytes (pbl) to parasite antigens soluble protein third stage larvae (spl3) and soluble protein adult stage ( spa), non-parasite antigen ovalbumin (ova) were examined. there was substantial differences between hr and lr guinea pigs in the rate of acquisition of responsiveness to t...

background: macrophage immune responses are affected by the secretory proteins of mycobacterium tuberculosis (mtb). this study aimed to examine the immune responses of macrophages to mtb secretory antigens, namely esat-6, cfp-10, and esat-6/cfp-10. methods: thp-1 cells (a human monocytic cell line) were cultured and differentiated to macrophages by phorbol 12-myristate 13-acetate. the cytotoxic...

potassium channels allow potassium flux and are essential for the generation of electric current acrossexcitable membranes. potassium channels are also the targets of various intracellular controlmechanisms; such that the suboptimal regulation of channel function might be related to pathologicalconditions. realistic studies of ion current in biologic channels present a major challenge for compu...

background: numerous studies used microarray gene expression data to extract metastasis-driving gene signatures for the prediction of breast cancer relapse. however, the accuracy and generality of the previously introduced biomarkers are not acceptable for reliable usage in independent datasets. this inadequacy is attributed to ignoring gene interactions by simple feature selection methods, due...

this study was performed in order to evaluate the effects of irrigation and application of zn fertilizer on  seed storage proteins  in chickpea, azad cultivar. experiment was performed in an factorial using randomized complete block design with three replications. in this experiment, two factor consist of irrigation in three levels (i1= non irrigation and i2= irrigation in flowering stage), zn ...

saliva is multifunctional; it is a lubricant for speech, aide for food digestion, and protective against microorganisms. it is voluntarily accessible, composed of proteins and electrolytes, and is ideal for the early detection of a wide range of diseases. because of a complex protein mixture, saliva proteomics has the potential to be a novel approach in the search for protein biomarkers. most s...

PROSITE database contains a set of entries corresponding to protein families, which are used to identify the family of a protein from its sequence. Although patterns and profiles are developed to be very selective, each may have false positive or negative hits. Considering false positives as items that reduce the selectiveness of a pattern, then, the more selective pattern we have, a more accur...

aim: this study is aimed to elicit the possible correlation between breast and colon cancer from molecular prospectiveby analyzing and comparing pathway-based biomarkers.background: breast and colon cancer are known to be frequent causes of morbidity and mortality in men and womenaround the world. there is some evidence that while the incident of breast cancer in young women is high, it is repo...

data regarding the effects of dietary protein on modifying serum lipid and lipoprotein levels are controversial. in this study we have investigated the hypothesis whether dietary protein and protein to carbohydrate ratio could be related to subsequent changes in lipid profile in adults.this 3-yaers follow-up_longitudinal study was conducted on a sample of participants (845 men and 1043 women, a...

objective too much restriction of dietary proteins can cause severe protein malnutrition,which can occur in adjusting the diet for some kinds of aminoacidopathies, urea cycle disorder and organic academia. this report presents the case of a 1.5-year-old boy with history of phenylketonuria with a three weeks history of erythematous scaly plaques and edema of his extremities; he had a history of ...