Rosuvastatin is a new generation HMG-CoA reductase inhibitor which exhibits some unique pharmacologic and pharmacokinetic properties. It has low extrahepatic tissue penetration, low potential for CYP3A4 interactions and substantial LDL-C lowering capacity and therefore has distinct advantages. We conducted a Medline literature search to identify rosuvastatin papers published in English. In this...

Purpose: This study aimed to determine the functional effects and mechanisms of action rosuvastatin on vascular tracheal smooth muscle tissues. 
 Materials Methods: Vascular rings (2-3 mm) isolated from thoracic aortas, pulmonary arteries, tracheas Wistar Albino male rats (250-300 g) were placed in chambers tissue bath system. As resting tension, 1 g was selected. contracted with 10-6 M ph...

Development and validation of two simple, rapid, precise, accurate and sensitive UV spectrophotometric methods for the simultaneous estimation of Rosuvastatin calcium and Aspirin in bulk and in capsule dosage form. The methods are based on the measurement of absorbance of Rosuvastatin calcium and Aspirin at 241nm and 296nm respectively. The linearity of the calibration curves for Rosuvastatin c...

Objective: The purpose of the present study was to reveal the potential pleotropic anti-inflammatory activity of two hmg-co Reductase inhibitors, Rosuvastatin and atorvastatin in comparison with standard drug diclofenac. Methods: The method used for screening anti-inflammatry activity was In vitro human red blood cell membrane stabilization method. Results: The results of our study revealed tha...

Dual antiplatelet agents and high-intensity statins are frequently used in combination after myocardial infarction. Ticagrelor has the potential of causing acute kidney injury. Rosuvastatin is excreted through the kidneys and dose adjustment is needed in patients with kidney disease. When used in combination, they can potentiate the toxic effects of each other. We report a case of drug interact...

Abstract Introduction In patients undergoing cardiac surgery, perioperative statin therapy does not prevent atrial fibrillation or myocardial injury, but results in increased creatinine levels after surgery. Here we investigated the incidence of acute kidney injury (AKI) 1922 scheduled for elective surgery who were randomized to rosuvastatin (20 mg once daily) placebo Statin Therapy Cardiac Sur...

BACKGROUND Quality and quantity of high-density lipoprotein cholesterol (HDL-C) may be associated with cardiovascular risk. We investigated the effect of rosuvastatin on cholesterol efflux (CE) for HDL function and vascular health.Methods and Results:We enrolled 30 dyslipidemic patients with type 2 diabetes mellitus and 20 healthy subjects as controls. Vascular health was assessed on flow-medic...

CONTEXT The present review aimed at reviewing the effects of different statins on lipid profile, particularly in Asians. EVIDENCE ACQUISITION PubMed searches were conducted using the keywords 'statin, effect, and lipid profile' from database inception through March 2016. In this review, 718 articles were retrieved from the primary search. After reviewing the titles, abstracts, and full texts,...

Rosuvastatin is a new statin that has been shown to produce substantial dose-dependent reductions in low-density lipoprotein cholesterol (LDL-C) in Western and Japanese hypercholesterolemic patients. Rosuvastatin efficacy and safety were assessed in an open-label, dose-titration trial of 37 Japanese patients with heterozygous familial hypercholesterolemia. After an 8-week dietary lead-in period...

BACKGROUND Although the beneficial effects of statin treatment in dyslipidemia and atherosclerosis have been well studied, there is limited information regarding the renal effects of statins in diabetic nephropathy. We aimed to investigate whether, and which, statins affected renal function in Asian patients with diabetes. METHODS We enrolled 484 patients with diabetes who received statin tre...