Major advances in vision research and clinical ophthalmology have occurred because of seminal findings by individual investigators, usually though only after years of persistent, hard work. I believe this to be the case with the work of Dr. Gustavo Aguirre in developing, characterizing, and subsequently using his unique animal models of inherited retinal degeneration (RD) in preclinical safety ...

The insulin-like growth factor (IGF) binding proteins (IGFBPs) were initially identified as carrier proteins for IGF-I and IGF-II in a variety of biologic fluids. Their presumed function was to protect IGF peptides from degradation and clearance, increase the halflife of the IGFs, and deliver them to appropriate tissue receptors. The concept of IGFBPs as simple carrier proteins has been complic...

UDP-glucuronosyltransferases (UGTs) of the UGT2B family conjugate steroid hormones as well as bile acids and xenobiotics. UGT2Bs are expressed in numerous human tissues, such as skin, breast, prostate, adipose, and intestine and are hypothesized to modulate steroid metabolism and excretion. Polymorphisms have been identified that may modify substrate specificities or enzyme activities of UGT2B ...

Acta Trop. 2009 Mar;109(3):245-6. Automated detection of haemozoin-containing monocytes for the diagnosis of malaria in microscopically negative cases during pregnancy. Hänscheid T, Längin M, Codices V, Luty AJ, Adegnika AA, Kremsner PG, Grobusch MP. Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon. Plasmodium falciparum sequesters in the placenta. Cell-Dyn automated flow cyt...