rs9939609 polymorphism

Marian Tanofsky-Kraff Joan C Han Kavitha Anandalingam Lauren B Shomaker Kelli M Columbo Laura E Wolkoff Merel Kozlosky Camden Elliott Lisa M Ranzenhofer Caroline A Roza Susan Z Yanovski Jack A Yanovski

BACKGROUND Children with rs9939609 FTO variant alleles (homozygous = AA and heterozygous = AT) are predisposed to greater adiposity than are those with 2 wild-type alleles (TT). OBJECTIVE Because FTO is highly expressed in hypothalamic regions that are important for appetite, FTO genotype may affect energy balance by influencing eating behavior. Loss of control (LOC) eating, a behavior common...

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An FTO variant is associated with Type 2 diabetes in South Asian populations after accounting for body mass index and waist circumference.

Journal: :Diabetic medicine : a journal of the British Diabetic Association 2011

S D Rees M Islam M Z I Hydrie B Chaudhary S Bellary S Hashmi J P O'Hare S Kumar D K Sanghera N Chaturvedi A H Barnett A S Shera M N Weedon A Basit T M Frayling M A Kelly T H Jafar

AIMS A common variant, rs9939609, in the FTO (fat mass and obesity) gene is associated with adiposity in Europeans, explaining its relationship with diabetes. However, data are inconsistent in South Asians. Our aim was to investigate the association of the FTO rs9939609 variant with obesity, obesity-related traits and Type 2 diabetes in South Asian individuals, and to use meta-analyses to attem...

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