Spliceosome-mediated RNA trans-splicing (SMaRT) is a molecular tool that facilitates genetic reprogramming on the RNA level (Wally et al., 2012). SMaRT exploits the cells own splicingmachinery to recombine two RNA molecules: the endogenous RNA target and the RNA trans-splicing molecule (RTM). The end product is a chimeric RNA wherein part of the message encoded by the target RNA is replaced wit...

The future German Environmental Mapping and Analysis Program (EnMAP) mission, due to launch in late 2019, will deliver high resolution hyperspectral data from space and will thus contribute to a better monitoring of the dynamic surface of the earth. Exploiting the satellite’s ±30◦ across-track pointing capabilities will allow for the collection of hyperspectral time-series of homogeneous qualit...

In the last few chapters we have looked at the first stages in a process toward establishing trust between systems. First, the establishment of roots of trust and the measured boot components; and second, the collection of evidence throughout the measurement process. We reviewed the different roots of trust in a compute platform—namely, the RTM, RTS, and RTR—and how the measured boot process (S...

Naphthalene is a nasal carcinogen, inducing respiratory adenomas in male and olfactory neuroblastomas in female rats, respectively. The reasons for the site and sex-specific tumorigenic response are unknown. Naphthalene is bioactivated to electrophilic metabolites; cytotoxicity followed by regenerative cell proliferation is likely involved in the tumorigenic response. To examine sex differences...

Resin transfer moulding (RTM) is a widely used process for manufacturing composite parts. It is currently gaining market shares compared to autoclave process in particular for high performance applications, such as aerospace, thanks to its higher versatility permitting the manufacturing of complex and high quality composite parts in fairly short cycle times. The major disadvantage of RTM remain...

Background In recent years the use of Biologics (B) at management systemic lupus erythematosus including with juvenile onset (jSLE) has increased. Belimumab (BEL) became first approved B for SLE. The rituximab (RTM), despite status “of label”, remains relevant in a number patients (pts) poor response to standard therapy and presence life-threatening conditions. However, real clinical practice i...

Accurate surface temperature retrieval using thermal infrared observations from satellites is important for surface energy balance modeling; however it is difficult to achieve without proper correction for atmospheric effects. Typically the atmospheric correction is obtained from radiosonde profiles and a radiative transfer model (RTM). But rigorous RTM processing is impractical for routine con...

The standard reverse-time migration (RTM) algorithm is usually described as zero-lag correlation of the backprojected data with the source wavefield. The data are back-projected by a finite-difference algorithm, where each trace acts as a source-time history of a point source at the geophone location. This is a simple and easily understood migration method, but appears inflexible to improvement...