A rubella outbreak occurred in Anqing city of Anhui province, China, from February to July of 2012, and a total of 241 clinically diagnosed or lab-confirmed patients were reported. The highest number of rubella cases during this outbreak was recorded in teenagers between 10 and 19 years of age who had not previously received the rubella vaccine. Genotyping results indicated that the genotype 2B...

measles, mumps and rubella are viral infectious diseases that may result in serious complications. since the production of vaccines, the number of cases of these diseases has been dropped. nevertheless, these infectious diseases are still one of the major health problems in developing countries. in this study, in order to evaluate the protective responses against measles, mumps and rubella, the...

Rubella and congenital rubella syndrome (CRS) continue to be important health problems in many countries. In June 2004, the World Health Organization Steering Committee on Research Related to Measles and Rubella Vaccines and Vaccination met to evaluate data from research and operational activities and to identify critical scientific issues and gaps in knowledge that need to be addressed to impr...

Congenital hearing loss is a sensory impairment affecting the speech and language development of a child. There are various causes leading to the congenital loss of hearing. One of the most common causes is the infection due to Rubella virus [1]. Rubella (German measles) is contagious viral infection caused by Rubella virus (RuV) to the fetus during pregnancy [2] WHO (World health organisation)...

In congenital rubella an acid-labile alpha-interferon was present in sera collected from fetuses between weeks 21 and 29 of gestation and from children with active congenital rubella. This interferon was different from the interferon detected in normal amniotic fluid and was not found in sera from uninfected fetuses or from children with postnatally acquired rubella. The fetal interferon is of ...

Although the data are not available, it seems that the risk to the fetus of asymptomatic reinfection is small,3" and certainly it is far less than that of primary rubella. In the rare cases of symptomatic reinfection viraemia may be presumed to have occurred, putting the fetus at appreciable risk.9 An antibody response may be confidently ascribed to reinfection if two or more previous positive ...

We have developed and tested a method for printing protein microarrays on glass slides and using these microarrays in a comparative fluorescence assay to detect TORCH infections. We generated protein microarrays by printing antibodies to simultaneously determine infections of TORCH (toxoplasmosis-rubella-cytomegalovirus-herpes) by detecting antibodies against Toxoplasma gondii, rubella virus, c...

In vitro rubella virus infections of lymphocytes from normal adult humans impaired their responsiveness to phytohemagglutinin (PHA) stimulations; a situation which seemed analogous to the PHA unresponsiveness of peripheral lymphocytes from babies with the congenital rubella syndrome. Such in vitro viral infection of normal cells also decreased the synthesis of normal nucleic acids and structura...

Viral infections during pregnancy are a significant cause of infant morbidity and mortality. Of these, rubella virus infection is a well-substantiated example that leads to miscarriages or severe fetal defects. However, structural information about the rubella virus has been lacking due to the pleomorphic nature of the virions. Here we report a helical structure of rubella virions using cryo-el...

BACKGROUND Infection of mothers with Rubella virus during pregnancy can be serious; if the mother is infected within the first 20 weeks of pregnancy she is likely to have miscarriage, stillbirth, or baby with congenital rubella syndrome. This study was carried out to define Rubella virus seroprevalence in pregnancy in Osogbo, Nigeria. METHODS This study is a cross-sectional sero-survey of rub...