Familial hypoplasia of the iris stroma associated with glaucoma has been recorded on four occasions, this being the first report in the English literature. In all cases the condition has been inherited as an autosomal dominant trait. Berg (1932) described thirteen men and nine women affected in six generations. They were first seen between the ages of I6 and 43 years, and eight eventually becam...

Routine ophthalmoscopy and fundoscopy of 673 individuals revealed 42 whose irides failed to dilate to a clinically useful degree within 25 to 30 min after the administration of drops of 1% mydracil. These individuals occurred with different frequency among the Aymara, Mestizo, and non-Aymara groups which made up the sample of examinees. The phenomenon was most common among the Aymara, less comm...

John R. Campbell MD and I recently reported on two companion studies that we undertook to study the incidence, characteristics, surgical outcomes, and etiology of floppy irides during cataract surgery1. We named this condition the intraoperative floppy iris syndrome (IFIS). Based upon retrospective observations by Dr. Campbell regarding a possible association with tamsulosin (Flomax®, Boehringe...

A child born of a full-term pregnancy had unilateral splitting of the anterior segment of the right eye associated with choristoma. No other craniofacial abnormalitieswere found. The globe was slightly increased in size but was normal in shape. The 2 corneas were separated by a choristoma. Pathological examination revealed splitting of the anterior segment with 2 corneas, 2 lenses, and 2 irides...

Electron microscopy was performed on the irides of a man with a history of a long standing Horner's syndrome which resulted in iris heterochromia. Comparison of his normal brown iris with the depigmented blue iris showed depletion of anterior border cells and absence of sympathetic nerve fibres. Stromal melanocyte numbers were also diminished but melanosome numbers within the residual cells wer...

PURPOSE To evaluate the efficacy of intraocular injections with bevacizumab in patients with macular edema (ME) secondary to central retinal vein occlusion (CRVO). DESIGN Prospective, randomized, sham injection-controlled, double-masked clinical trial. PARTICIPANTS Sixty patients with ME secondary to CRVO. METHODS At baseline, patients were randomized 1:1 to receive intraocular injections...