Spike-timing-dependent plasticity (STDP) is described by long-term potentiation (LTP), when a presynaptic event precedes a postsynaptic event, and by long-term depression (LTD), when the temporal order is reversed. In this article, we present a biophysical model of STDP based on a differential Hebbian learning rule (ISO learning). This rule correlates presynaptically the NMDA channel conductanc...

OBJECTIVE To predict the development of carcinoid heart disease (CHD), which is a life-threatening complication of certain neuroendocrine tumors. To this end, a novel type of Bayesian classifier, known as the noisy-threshold classifier, is applied. MATERIALS AND METHODS Fifty-four cases of patients that suffered from a low-grade midgut carcinoid tumor, of which 22 patients developed CHD, were...

A receiver operating characteristic (ROC) curve is a plot of predictive model probabilities of true positives (sensitivity) as a function of probabilities of false positives (1 – specificity) for a set of possible cutoff points. Some of the SAS/STAT procedures do not have built-in options for ROC curves and there have been a few suggestions in previous SAS forums to address the issue by using e...

A particular version of the Westgard-Barry-Hunt-Groth (Westgard) multi-rule quality-control system is studied by Monte Carlo simulation. The principal focus is on the amount of distortion in the working power curve caused by skewness in the distribution of analyte measurements. The effect of using only the first two rejection modes of the Westgard system is also studied.

Abstract We prove that $164\, 634\, 913$ is the smallest positive integer a sum of two rational sixth powers, but not powers. If $C_{k}$ curve $x^{6} + y^{6} = k$ , we use existence morphisms from to elliptic curves, together with Mordell–Weil sieve, rule out points on for various k .

Ventricular fibrillation is the cause of the most sudden mortalities. Restitution is one of the specific properties of ventricular cell. The recent findings have clearly proved the correlation between the slope of restitution curve with ventricular fibrillation. This; therefore, mandates the modeling of cellular restitution to gain high importance. A cellular automaton is a powerful tool for si...

In spike-timing-dependent plasticity (STDP) the synapses are potentiated or depressed depending on the temporal order and temporal difference of the pre- and post-synaptic signals. We present a biophysical model of STDP which assumes that not only the timing, but also the shapes of these signals influence the synaptic modifications. The model is based on a Hebbian learning rule which correlates...

INTRODUCTION The aim of this study was to derive and internally validate a prediction rule for short stay admissions (SSAs) in trauma patients admitted to a major trauma centre. METHODS A retrospective study of all trauma activation patients requiring inpatient admission at a single inner city major trauma centre in Australia between 2007 and 2011 was conducted. Logistic regression was used t...