BACKGROUND Many medications can be used safely and effectively to provide health benefits for disease state management during pregnancy with minimal risk to the fetus or mother. Today nine out of ten women take at least one medication during pregnancy, and the number of women taking four or more medications has more than doubled over the past 30 years. However, the lack of safety data combined ...

There are many false assumptions, both in the general population and among physicians, regarding the influence of radiation on pregnant patients and the fetus during diagnostic procedures, in spite of scientific facts based on studies. These false assumptions are mostly based on the idea that every diagnostic procedure using ionizing radiation is a cause for serious concern and that artificial ...

Alternative drugs to chloroquine are required to prevent the deleterious effects of malaria in pregnancy. Fear of potential toxicity has limited antimalarial drug use in pregnancy. Animal toxicity studies have documented teratogenicity when antimalarials are administered at high dosages. Excepting the tetracyclines, there is no evidence to suggest that, at standard dosages, any of the antimalar...

Abstract Overview of: Medicines and Healthcare products Regulatory Agency. Antiepileptic drugs in pregnancy: updated advice following comprehensive safety review. Drug Safety Update 2021;14(6):1.

Heterotopic pregnancy is rare under natural circumstance (conception). We report the first case of heterotopic pregnancy in spontaneous conception with four previous caesarean sections and ruptured tubal ectopic with resultant successful normal intra-uterine pregnancy delivered at term after salpingectomy. A 32-year-old gravida 5 para 4+0 with 3 living children, with 4 previous caesarean sectio...

51 Received February 17, 2014; revised and accepted August 7, 2014. Published online August 30, 2014; doi: 10.1620/tjem.234.51. Correspondence: Yasumori Izumi, M.D., Department of General Internal Medicine, Nagasaki Medical Center, Kubara 2-1001-1, Omura, Nagasaki 856-8652, Japan. e-mail: [email protected] Safety of Tacrolimus Treatment during Pregnancy and Lactation in Systemic Lupus Eryt...

Commentary In utero exposure to first-generation antiepileptic drugs (AEDs) has been shown to increase the risk of congenital malforma-tions and cognitive deficits (1). The risk of major congenital malformations with AED exposure is estimated to be between 4 and 9 percent, compared with the background risk of 1 to 2 percent (2). Prenatal exposure to different older-generation AEDs has been asso...

Preterm labor (PTL) is a major cause of neonatal morbidity and mortality worldwide. Among the available tocolytics, indomethacin, a prostaglandin synthetase inhibitor, has been in use since the 1970s. Recent studies have suggested that prostaglandin synthetase inhibitors are superior to other tocolytics in delaying delivery for 48 hours and 7 days. However, increased neonatal complications incl...

In order to improve the control of diabetes, insulin analogs with duration of action longer or shorter than traditional insulins, (regular and neutral protamine Hagedorn) have been developed and have shown to provide better glucose control and also decrease the rate of hypoglycemia in patients with diabetes [1-3]. Strict control of hyperglycemia is essential to reduce adverse maternal and fetal...